HNRNPL [The Human Chemical-Genetic Interaction Map Project]

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======= HNRNPL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNRNPL
  * **<color #00a2e8>Official Name</color>**: heterogeneous nuclear ribonucleoprotein L
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3191|3191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14866|P14866]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNRNPL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNRNPL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603083|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pre-mRNA intronic binding|
|ribonucleoprotein granule|
|regulation of alternative mRNA splicing, via spliceosome|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|ribonucleoprotein complex|
|transcription regulatory region DNA binding|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.32|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.78|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.76|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.79|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.82|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.73|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|5.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cxorf38|CXorf38]]|0.525|
|[[:human genes:f:fadd|FADD]]|0.467|
|[[:human genes:e:elavl1|ELAVL1]]|0.441|
|[[:human genes:c:casp8|CASP8]]|0.436|
|[[:human genes:c:casp3|CASP3]]|0.435|
|[[:human genes:c:ccnc|CCNC]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 177/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|9/28|
|bone|7/26|
|breast|6/33|
|central nervous system|14/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|7/21|
|liver|2/20|
|lung|18/75|
|lymphocyte|5/16|
|ovary|6/26|
|pancreas|5/24|
|peripheral nervous system|2/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|3/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1123
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNRNPL Expression in NALM6 Cells: 9.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>