HOXD13 [The Human Chemical-Genetic Interaction Map Project]

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======= HOXD13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HOXD13
  * **<color #00a2e8>Official Name</color>**: homeobox D13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3239|3239]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35453|P35453]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HOXD13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HOXD13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142989|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed:24789103). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity). {ECO:0000250|UniProtKB:P24344, ECO:0000269|PubMed:24789103}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HoxA13 N|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|embryonic hindgut morphogenesis|
|prostate glandular acinus morphogenesis|
|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|
|regulation of branching involved in prostate gland morphogenesis|
|hindgut morphogenesis|
|hindgut development|
|branching involved in prostate gland morphogenesis|
|prostate glandular acinus development|
|branch elongation of an epithelium|
|morphogenesis of an epithelial fold|
|prostate gland epithelium morphogenesis|
|male genitalia development|
|enhancer sequence-specific DNA binding|
|prostate gland morphogenesis|
|axis elongation|
|response to testosterone|
|prostate gland development|
|genitalia development|
|digestive tract morphogenesis|
|regulation of morphogenesis of a branching structure|
|embryonic digit morphogenesis|
|gland morphogenesis|
|developmental growth involved in morphogenesis|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|digestive tract development|
|digestive system development|
|appendage morphogenesis|
|limb morphogenesis|
|male sex differentiation|
|morphogenesis of a branching epithelium|
|regulation of reproductive process|
|morphogenesis of a branching structure|
|limb development|
|regulation of morphogenesis of an epithelium|
|appendage development|
|response to ketone|
|anterior/posterior pattern specification|
|regulation of animal organ morphogenesis|
|sex differentiation|
|urogenital system development|
|regionalization|
|developmental growth|
|growth|
|chromatin binding|
|gland development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|transcription by RNA polymerase II|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|tissue morphogenesis|
|embryonic morphogenesis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|tube development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|embryo development|
|regulation of anatomical structure morphogenesis|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|DNA binding|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.85|
|[[:results:exp302|35°C R06 exp302]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9550
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HOXD13 Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>