HPCA [The Human Chemical-Genetic Interaction Map Project]

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======= HPCA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HPCA
  * **<color #00a2e8>Official Name</color>**: hippocalcin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3208|3208]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P84074|P84074]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HPCA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HPCA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142622|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide- mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity). {ECO:0000250|UniProtKB:P84076, ECO:0000269|PubMed:28398555}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to monosodium glutamate|
|response to ketamine|
|response to Aroclor 1254|
|response to monosodium glutamate|
|negative regulation of guanylate cyclase activity|
|negative regulation of nucleotide biosynthetic process|
|negative regulation of purine nucleotide biosynthetic process|
|activation of phospholipase D activity|
|cellular response to salt|
|positive regulation of adenylate cyclase activity|
|dendritic spine head|
|regulation of postsynaptic neurotransmitter receptor internalization|
|response to L-glutamate|
|regulation of guanylate cyclase activity|
|cellular response to electrical stimulus|
|negative regulation of purine nucleotide metabolic process|
|negative regulation of nucleotide metabolic process|
|response to salt|
|negative regulation of cyclase activity|
|negative regulation of lyase activity|
|positive regulation of cyclase activity|
|positive regulation of lyase activity|
|neuronal cell body membrane|
|regulation of adenylate cyclase activity|
|dendrite membrane|
|positive regulation of protein targeting to membrane|
|dendrite cytoplasm|
|regulation of voltage-gated calcium channel activity|
|regulation of protein targeting to membrane|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|response to electrical stimulus|
|regulation of cyclase activity|
|regulation of lyase activity|
|regulation of receptor internalization|
|positive regulation of phospholipase activity|
|extrinsic component of membrane|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|response to anesthetic|
|regulation of protein targeting|
|cellular response to calcium ion|
|regulation of calcium ion transmembrane transporter activity|
|negative regulation of small molecule metabolic process|
|kinase binding|
|regulation of lipase activity|
|regulation of receptor-mediated endocytosis|
|response to amino acid|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|positive regulation of protein localization to membrane|
|perikaryon|
|retina development in camera-type eye|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|response to calcium ion|
|positive regulation of intracellular protein transport|
|regulation of cation channel activity|
|regulation of protein localization to membrane|
|cellular response to metal ion|
|response to ketone|
|inner ear development|
|regulation of endocytosis|
|positive regulation of intracellular transport|
|response to nutrient|
|cellular response to inorganic substance|
|ear development|
|regulation of intracellular protein transport|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|actin binding|
|regulation of transporter activity|
|axon|
|response to xenobiotic stimulus|
|camera-type eye development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|response to acid chemical|
|glutamatergic synapse|
|regulation of intracellular transport|
|eye development|
|visual system development|
|sensory system development|
|response to metal ion|
|regulation of metal ion transport|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|positive regulation of establishment of protein localization|
|regulation of ion transmembrane transport|
|response to nutrient levels|
|response to toxic substance|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of cellular protein localization|
|sensory organ development|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|regulation of ion transport|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|head development|
|negative regulation of catalytic activity|
|regulation of cellular localization|
|response to organic cyclic compound|
|central nervous system development|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|regulation of protein localization|
|identical protein binding|
|response to nitrogen compound|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10436
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HPCA Expression in NALM6 Cells: -3.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>