HPSE [The Human Chemical-Genetic Interaction Map Project]

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======= HPSE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HPSE
  * **<color #00a2e8>Official Name</color>**: heparanase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10855|10855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y251|Q9Y251]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HPSE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HPSE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604724|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up- regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis. {ECO:0000269|PubMed:12213822, ECO:0000269|PubMed:12773484, ECO:0000269|PubMed:15044433, ECO:0000269|PubMed:16452201, ECO:0000269|PubMed:18557927, ECO:0000269|PubMed:18798279, ECO:0000269|PubMed:19244131, ECO:0000269|PubMed:20097882, ECO:0000269|PubMed:20181948, ECO:0000269|PubMed:20309870, ECO:0000269|PubMed:20561914, ECO:0000269|PubMed:21131364}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 79n|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|heparanase activity|
|heparan sulfate proteoglycan catabolic process|
|proteoglycan catabolic process|
|beta-glucuronidase activity|
|vascular wound healing|
|syndecan binding|
|positive regulation of osteoblast proliferation|
|positive regulation of hair follicle development|
|positive regulation of hair cycle|
|angiogenesis involved in wound healing|
|regulation of hair follicle development|
|glycoprotein catabolic process|
|regulation of osteoblast proliferation|
|positive regulation of blood coagulation|
|positive regulation of hemostasis|
|positive regulation of coagulation|
|regulation of hair cycle|
|positive regulation of vascular endothelial growth factor production|
|regulation of vascular endothelial growth factor production|
|heparan sulfate proteoglycan metabolic process|
|positive regulation of epidermis development|
|positive regulation of wound healing|
|glycosaminoglycan catabolic process|
|specific granule lumen|
|positive regulation of response to wounding|
|aminoglycan catabolic process|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|regulation of epidermis development|
|proteoglycan metabolic process|
|lysosomal lumen|
|cell-matrix adhesion|
|regulation of wound healing|
|glycosaminoglycan metabolic process|
|protein dimerization activity|
|positive regulation of protein kinase B signaling|
|aminoglycan metabolic process|
|regulation of response to wounding|
|cell-substrate adhesion|
|carbohydrate derivative catabolic process|
|regulation of protein kinase B signaling|
|membrane raft|
|extracellular matrix|
|lysosome|
|lysosomal membrane|
|angiogenesis|
|glycoprotein metabolic process|
|blood vessel morphogenesis|
|positive regulation of cytokine production|
|wound healing|
|neutrophil degranulation|
|blood vessel development|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|vasculature development|
|myeloid leukocyte mediated immunity|
|cardiovascular system development|
|myeloid cell activation involved in immune response|
|response to wounding|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|tube morphogenesis|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|regulation of cytokine production|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|secretion by cell|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of developmental process|
|regulation of response to stress|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-2.03|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.92|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16759
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HPSE Expression in NALM6 Cells: 2.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>