HRAS [The Human Chemical-Genetic Interaction Map Project]

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======= HRAS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HRAS
  * **<color #00a2e8>Official Name</color>**: HRas proto-oncogene, GTPase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3265|3265]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01112|P01112]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HRAS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HRAS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). {ECO:0000269|PubMed:12740440, ECO:0000269|PubMed:14500341, ECO:0000269|PubMed:22821884, ECO:0000269|PubMed:9020151}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|GTP EFTU|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of miRNA metabolic process|
|response to isolation stress|
|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|
|regulation of miRNA metabolic process|
|positive regulation of ruffle assembly|
|regulation of receptor localization to synapse|
|positive regulation of actin cytoskeleton reorganization|
|T-helper 1 type immune response|
|defense response to protozoan|
|response to protozoan|
|regulation of protein localization to synapse|
|regulation of long-term neuronal synaptic plasticity|
|regulation of ruffle assembly|
|cellular response to gamma radiation|
|positive regulation of protein targeting to membrane|
|cellular senescence|
|positive regulation of DNA replication|
|regulation of actin cytoskeleton reorganization|
|regulation of protein targeting to membrane|
|positive regulation of phospholipase C activity|
|regulation of phospholipase C activity|
|negative regulation of GTPase activity|
|regulation of neuronal synaptic plasticity|
|positive regulation of wound healing|
|response to gamma radiation|
|positive regulation of phospholipase activity|
|positive regulation of response to wounding|
|positive regulation of interferon-gamma production|
|positive regulation of Ras protein signal transduction|
|cell aging|
|cellular response to ionizing radiation|
|positive regulation of small GTPase mediated signal transduction|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|GDP binding|
|regulation of protein targeting|
|ephrin receptor signaling pathway|
|regulation of lipase activity|
|regulation of interferon-gamma production|
|positive regulation of plasma membrane bounded cell projection assembly|
|protein heterooligomerization|
|regulation of DNA replication|
|stimulatory C-type lectin receptor signaling pathway|
|regulation of protein localization to cell periphery|
|innate immune response activating cell surface receptor signaling pathway|
|positive regulation of protein localization to membrane|
|regulation of wound healing|
|positive regulation of JNK cascade|
|negative regulation of neuron apoptotic process|
|cell cycle arrest|
|response to ionizing radiation|
|intrinsic apoptotic signaling pathway|
|mitotic cell cycle checkpoint|
|positive regulation of intracellular protein transport|
|positive regulation of stress-activated MAPK cascade|
|regulation of response to wounding|
|positive regulation of stress-activated protein kinase signaling cascade|
|cellular response to radiation|
|T cell receptor signaling pathway|
|regulation of JNK cascade|
|positive regulation of epithelial cell proliferation|
|regulation of synaptic plasticity|
|protein C-terminus binding|
|regulation of protein localization to membrane|
|cell cycle checkpoint|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|positive regulation of intracellular transport|
|positive regulation of ERK1 and ERK2 cascade|
|positive regulation of cytoskeleton organization|
|regulation of intracellular protein transport|
|regulation of stress-activated MAPK cascade|
|innate immune response-activating signal transduction|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|activation of innate immune response|
|positive regulation of MAP kinase activity|
|aging|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|apoptotic signaling pathway|
|regulation of ERK1 and ERK2 cascade|
|antigen receptor-mediated signaling pathway|
|negative regulation of mitotic cell cycle|
|regulation of neuron death|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|small GTPase mediated signal transduction|
|positive regulation of cellular protein localization|
|GTPase activity|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|regulation of intracellular transport|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|GTP binding|
|signal transduction by protein phosphorylation|
|positive regulation of GTPase activity|
|positive regulation of protein transport|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|positive regulation of establishment of protein localization|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|endocytosis|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|mitotic cell cycle process|
|positive regulation of response to external stimulus|
|adaptive immune response|
|Golgi membrane|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|activation of immune response|
|positive regulation of transferase activity|
|import into cell|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|apoptotic process|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|cell cycle|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9816
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HRAS Expression in NALM6 Cells: 4.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>