HRH2 [The Human Chemical-Genetic Interaction Map Project]

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======= HRH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HRH2
  * **<color #00a2e8>Official Name</color>**: histamine receptor H2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3274|3274]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25021|P25021]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HRH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HRH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142703|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gastrin-induced gastric acid secretion|
|histamine-induced gastric acid secretion|
|histamine receptor activity|
|gastric acid secretion|
|positive regulation of vasoconstriction|
|epithelial cell morphogenesis|
|G protein-coupled serotonin receptor activity|
|G protein-coupled serotonin receptor signaling pathway|
|neurotransmitter receptor activity|
|toxin transport|
|serotonin receptor signaling pathway|
|visual learning|
|visual behavior|
|regulation of vasoconstriction|
|positive regulation of blood circulation|
|digestive system process|
|associative learning|
|acid secretion|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to monoamine|
|response to catecholamine|
|digestion|
|memory|
|cellular response to ammonium ion|
|digestive tract development|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|digestive system development|
|learning|
|vascular process in circulatory system|
|response to ammonium ion|
|regulation of synaptic plasticity|
|epithelial cell development|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|learning or memory|
|regulation of blood circulation|
|cognition|
|response to light stimulus|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|gland development|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|trans-synaptic signaling|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of anatomical structure size|
|cellular response to organic cyclic compound|
|cell morphogenesis involved in differentiation|
|behavior|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|epithelial cell differentiation|
|cell morphogenesis|
|G protein-coupled receptor activity|
|cellular component morphogenesis|
|tube development|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|epithelium development|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.81|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.81|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10282
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HRH2 Expression in NALM6 Cells: 0.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>