HSD17B10 [The Human Chemical-Genetic Interaction Map Project]

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======= HSD17B10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSD17B10
  * **<color #00a2e8>Official Name</color>**: hydroxysteroid 17-beta dehydrogenase 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3028|3028]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99714|Q99714]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSD17B10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSD17B10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300256|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial dehydrogenase that catalyzes the beta- oxidation at position 17 of androgens and estrogens and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Catalyzes the third step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011). Also exhibits 20-beta- OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426). {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18996107, ECO:0000269|PubMed:20077426, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:9338779, ECO:0000269|PubMed:9553139}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KR|
|adh short|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cholate 7-alpha-dehydrogenase activity|
|3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity|
|dihydrotestosterone 17-beta-dehydrogenase activity|
|testosterone dehydrogenase [NAD(P)] activity|
|mitochondrial tRNA 5-end processing|
|mitochondrial tRNA 3-end processing|
|mitochondrial ribonuclease P complex|
|mitochondrial RNA 5-end processing|
|mitochondrial tRNA methylation|
|mitochondrial RNA 3-end processing|
|3-hydroxyacyl-CoA dehydrogenase activity|
|tRNA 3-end processing|
|mitochondrial tRNA modification|
|mitochondrial RNA modification|
|mitochondrial tRNA processing|
|tRNA 5-end processing|
|tRNA threonylcarbamoyladenosine metabolic process|
|mitochondrial RNA processing|
|ncRNA 5-end processing|
|RNA 5-end processing|
|branched-chain amino acid catabolic process|
|branched-chain amino acid metabolic process|
|tRNA methylation|
|mitochondrial RNA metabolic process|
|ncRNA 3-end processing|
|tRNA binding|
|RNA methylation|
|tRNA modification|
|protein homotetramerization|
|cellular amino acid catabolic process|
|tRNA processing|
|RNA 3-end processing|
|mitochondrial gene expression|
|protein tetramerization|
|RNA modification|
|tRNA metabolic process|
|macromolecule methylation|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|cellular amino acid metabolic process|
|methylation|
|protein homooligomerization|
|mitochondrial matrix|
|ncRNA processing|
|small molecule catabolic process|
|mitochondrion organization|
|ncRNA metabolic process|
|protein complex oligomerization|
|RNA processing|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|lipid metabolic process|
|mitochondrion|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.52|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.16|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.06|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.83|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.83|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.77|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.74|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.73|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.72|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.7|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.75|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.78|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.78|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.79|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.79|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.79|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.86|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.89|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.91|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.95|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.95|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.98|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.08|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.16|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.18|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.23|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.24|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.31|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.31|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.37|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.38|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.43|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.43|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.44|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.49|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.7|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.82|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.99|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.04|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.21|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|4.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dars2|DARS2]]|0.783|
|[[:human genes:t:tars2|TARS2]]|0.782|
|[[:human genes:m:mrpl21|MRPL21]]|0.772|
|[[:human genes:y:yars2|YARS2]]|0.771|
|[[:human genes:g:gfm1|GFM1]]|0.763|
|[[:human genes:m:mrps34|MRPS34]]|0.757|
|[[:human genes:s:sco2|SCO2]]|0.755|
|[[:human genes:m:mrps6|MRPS6]]|0.754|
|[[:human genes:s:selrc1|SELRC1]]|0.754|
|[[:human genes:d:dap3|DAP3]]|0.75|
|[[:human genes:q:qrsl1|QRSL1]]|0.749|
|[[:human genes:m:mrps21|MRPS21]]|0.745|
|[[:human genes:p:pars2|PARS2]]|0.744|
|[[:human genes:m:mrps16|MRPS16]]|0.741|
|[[:human genes:m:mrps14|MRPS14]]|0.738|
|[[:human genes:m:mrpl23|MRPL23]]|0.735|
|[[:human genes:n:nars2|NARS2]]|0.73|
|[[:human genes:m:mrp63|MRP63]]|0.728|
|[[:human genes:r:rars2|RARS2]]|0.722|
|[[:human genes:c:cox16|COX16]]|0.721|
|[[:human genes:b:bcs1l|BCS1L]]|0.706|
|[[:human genes:v:vars2|VARS2]]|0.705|
|[[:human genes:m:mrpl53|MRPL53]]|0.704|
|[[:human genes:r:rpusd4|RPUSD4]]|0.701|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.7|
|[[:human genes:m:mrps5|MRPS5]]|0.699|
|[[:human genes:m:mrps26|MRPS26]]|0.693|
|[[:human genes:m:mrps2|MRPS2]]|0.693|
|[[:human genes:t:tufm|TUFM]]|0.691|
|[[:human genes:m:mars2|MARS2]]|0.688|
|[[:human genes:l:lars2|LARS2]]|0.685|
|[[:human genes:w:wbscr16|WBSCR16]]|0.681|
|[[:human genes:e:ears2|EARS2]]|0.681|
|[[:human genes:c:c10orf2|C10orf2]]|0.68|
|[[:human genes:h:hars2|HARS2]]|0.675|
|[[:human genes:m:mrps18a|MRPS18A]]|0.673|
|[[:human genes:r:rbfa|RBFA]]|0.672|
|[[:human genes:f:fastkd5|FASTKD5]]|0.667|
|[[:human genes:m:mrpl47|MRPL47]]|0.664|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.661|
|[[:human genes:c:coa3|COA3]]|0.661|
|[[:human genes:s:sars2|SARS2]]|0.657|
|[[:human genes:a:aars2|AARS2]]|0.656|
|[[:human genes:m:mrps9|MRPS9]]|0.653|
|[[:human genes:f:fars2|FARS2]]|0.648|
|[[:human genes:n:ndufa3|NDUFA3]]|0.648|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.647|
|[[:human genes:m:mrps25|MRPS25]]|0.644|
|[[:human genes:g:gfm2|GFM2]]|0.643|
|[[:human genes:n:ndufb11|NDUFB11]]|0.641|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.641|
|[[:human genes:c:cox11|COX11]]|0.641|
|[[:human genes:m:mrpl15|MRPL15]]|0.639|
|[[:human genes:m:mrpl20|MRPL20]]|0.635|
|[[:human genes:m:mrpl3|MRPL3]]|0.634|
|[[:human genes:m:mtg2|MTG2]]|0.633|
|[[:human genes:m:mrpl45|MRPL45]]|0.632|
|[[:human genes:a:aifm1|AIFM1]]|0.627|
|[[:human genes:g:gatc|GATC]]|0.627|
|[[:human genes:c:c12orf65|C12orf65]]|0.626|
|[[:human genes:f:ftsj2|FTSJ2]]|0.622|
|[[:human genes:m:mrps33|MRPS33]]|0.622|
|[[:human genes:m:mrps24|MRPS24]]|0.62|
|[[:human genes:c:cox17|COX17]]|0.619|
|[[:human genes:c:cox7b|COX7B]]|0.616|
|[[:human genes:p:pet112|PET112]]|0.614|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.613|
|[[:human genes:p:polg2|POLG2]]|0.612|
|[[:human genes:s:slc25a26|SLC25A26]]|0.611|
|[[:human genes:a:atp5d|ATP5D]]|0.609|
|[[:human genes:m:mrpl55|MRPL55]]|0.609|
|[[:human genes:m:mrps12|MRPS12]]|0.609|
|[[:human genes:m:mtpap|MTPAP]]|0.608|
|[[:human genes:t:trub2|TRUB2]]|0.608|
|[[:human genes:p:pet117|PET117]]|0.602|
|[[:human genes:m:mrpl12|MRPL12]]|0.6|
|[[:human genes:c:coa6|COA6]]|0.595|
|[[:human genes:e:elac2|ELAC2]]|0.593|
|[[:human genes:p:pgm3|PGM3]]|0.593|
|[[:human genes:t:tefm|TEFM]]|0.592|
|[[:human genes:m:mrps23|MRPS23]]|0.591|
|[[:human genes:m:mrpl11|MRPL11]]|0.591|
|[[:human genes:p:pnpt1|PNPT1]]|0.587|
|[[:human genes:m:mrps10|MRPS10]]|0.586|
|[[:human genes:p:polg|POLG]]|0.585|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.584|
|[[:human genes:c:cox6c|COX6C]]|0.584|
|[[:human genes:m:mrpl42|MRPL42]]|0.584|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.582|
|[[:human genes:a:atp5a1|ATP5A1]]|0.579|
|[[:human genes:p:polrmt|POLRMT]]|0.579|
|[[:human genes:a:atp5c1|ATP5C1]]|0.578|
|[[:human genes:m:mrps11|MRPS11]]|0.577|
|[[:human genes:m:mettl17|METTL17]]|0.576|
|[[:human genes:n:ndufa2|NDUFA2]]|0.574|
|[[:human genes:t:tomm20|TOMM20]]|0.574|
|[[:human genes:m:mrpl43|MRPL43]]|0.573|
|[[:human genes:r:rpusd3|RPUSD3]]|0.573|
|[[:human genes:p:pdss1|PDSS1]]|0.568|
|[[:human genes:m:mrpl36|MRPL36]]|0.567|
|[[:human genes:d:dhrsx|DHRSX]]|0.562|
|[[:human genes:c:cox15|COX15]]|0.562|
|[[:human genes:n:ndufc2|NDUFC2]]|0.562|
|[[:human genes:n:ndufa1|NDUFA1]]|0.561|
|[[:human genes:r:rpia|RPIA]]|0.56|
|[[:human genes:c:c17orf89|C17orf89]]|0.558|
|[[:human genes:m:mrpl4|MRPL4]]|0.557|
|[[:human genes:l:lsm10|LSM10]]|0.556|
|[[:human genes:m:mrpl39|MRPL39]]|0.553|
|[[:human genes:n:ndufb5|NDUFB5]]|0.551|
|[[:human genes:m:mrps35|MRPS35]]|0.55|
|[[:human genes:f:fh|FH]]|0.548|
|[[:human genes:w:wars2|WARS2]]|0.548|
|[[:human genes:c:coa5|COA5]]|0.547|
|[[:human genes:m:mrps22|MRPS22]]|0.545|
|[[:human genes:t:tfam|TFAM]]|0.543|
|[[:human genes:m:mrpl44|MRPL44]]|0.543|
|[[:human genes:m:mtg1|MTG1]]|0.542|
|[[:human genes:d:dnlz|DNLZ]]|0.542|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.539|
|[[:human genes:n:ndufb6|NDUFB6]]|0.539|
|[[:human genes:t:tmem242|TMEM242]]|0.538|
|[[:human genes:n:ndufs2|NDUFS2]]|0.537|
|[[:human genes:h:hccs|HCCS]]|0.537|
|[[:human genes:c:chchd4|CHCHD4]]|0.536|
|[[:human genes:p:ppa2|PPA2]]|0.536|
|[[:human genes:t:triap1|TRIAP1]]|0.534|
|[[:human genes:a:atp5sl|ATP5SL]]|0.534|
|[[:human genes:u:uqcr10|UQCR10]]|0.531|
|[[:human genes:a:atp5b|ATP5B]]|0.53|
|[[:human genes:m:mrpl33|MRPL33]]|0.53|
|[[:human genes:m:malsu1|MALSU1]]|0.53|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.527|
|[[:human genes:m:mrpl18|MRPL18]]|0.526|
|[[:human genes:m:mrpl27|MRPL27]]|0.526|
|[[:human genes:t:tfb1m|TFB1M]]|0.521|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.52|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.519|
|[[:human genes:m:mrps7|MRPS7]]|0.516|
|[[:human genes:c:cox5a|COX5A]]|0.515|
|[[:human genes:m:mrps27|MRPS27]]|0.514|
|[[:human genes:a:atxn10|ATXN10]]|0.511|
|[[:human genes:c:chchd1|CHCHD1]]|0.511|
|[[:human genes:m:mrpl22|MRPL22]]|0.511|
|[[:human genes:d:dhx30|DHX30]]|0.51|
|[[:human genes:m:mterfd1|MTERFD1]]|0.509|
|[[:human genes:e:ecsit|ECSIT]]|0.508|
|[[:human genes:m:mrpl52|MRPL52]]|0.507|
|[[:human genes:m:mrpl17|MRPL17]]|0.503|
|[[:human genes:m:mrpl28|MRPL28]]|0.503|
|[[:human genes:c:cars2|CARS2]]|0.502|
|[[:human genes:n:ndufb3|NDUFB3]]|0.5|
|[[:human genes:a:alg6|ALG6]]|0.497|
|[[:human genes:v:vezt|VEZT]]|0.495|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.495|
|[[:human genes:c:cox6b1|COX6B1]]|0.494|
|[[:human genes:a:atp5h|ATP5H]]|0.494|
|[[:human genes:i:iba57|IBA57]]|0.493|
|[[:human genes:n:ndufa10|NDUFA10]]|0.493|
|[[:human genes:u:uqcrq|UQCRQ]]|0.492|
|[[:human genes:a:alg8|ALG8]]|0.492|
|[[:human genes:m:mrpl34|MRPL34]]|0.492|
|[[:human genes:m:mipep|MIPEP]]|0.491|
|[[:human genes:p:ppcs|PPCS]]|0.49|
|[[:human genes:m:mrpl13|MRPL13]]|0.489|
|[[:human genes:m:mrps17|MRPS17]]|0.487|
|[[:human genes:d:dpagt1|DPAGT1]]|0.487|
|[[:human genes:n:ndufv1|NDUFV1]]|0.486|
|[[:human genes:a:atp5j|ATP5J]]|0.485|
|[[:human genes:n:ndufa11|NDUFA11]]|0.485|
|[[:human genes:t:tomm6|TOMM6]]|0.484|
|[[:human genes:c:coq2|COQ2]]|0.483|
|[[:human genes:s:srd5a3|SRD5A3]]|0.481|
|[[:human genes:t:timm8b|TIMM8B]]|0.481|
|[[:human genes:a:acad9|ACAD9]]|0.481|
|[[:human genes:o:opa1|OPA1]]|0.481|
|[[:human genes:m:mterfd2|MTERFD2]]|0.48|
|[[:human genes:a:atp5o|ATP5O]]|0.48|
|[[:human genes:n:ndufs7|NDUFS7]]|0.479|
|[[:human genes:m:mrpl41|MRPL41]]|0.478|
|[[:human genes:a:atic|ATIC]]|0.477|
|[[:human genes:d:dolk|DOLK]]|0.477|
|[[:human genes:m:mrpl37|MRPL37]]|0.477|
|[[:human genes:p:ptcd3|PTCD3]]|0.475|
|[[:human genes:p:pmm2|PMM2]]|0.475|
|[[:human genes:p:pet100|PET100]]|0.474|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.473|
|[[:human genes:c:coq3|COQ3]]|0.473|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.472|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.472|
|[[:human genes:s:slc25a19|SLC25A19]]|0.472|
|[[:human genes:t:trmt61a|TRMT61A]]|0.471|
|[[:human genes:s:sdha|SDHA]]|0.47|
|[[:human genes:n:ndufb1|NDUFB1]]|0.47|
|[[:human genes:n:ndufb9|NDUFB9]]|0.467|
|[[:human genes:t:tpk1|TPK1]]|0.466|
|[[:human genes:g:grsf1|GRSF1]]|0.465|
|[[:human genes:u:uqcc2|UQCC2]]|0.465|
|[[:human genes:c:crls1|CRLS1]]|0.463|
|[[:human genes:m:mrpl49|MRPL49]]|0.462|
|[[:human genes:m:mrpl2|MRPL2]]|0.462|
|[[:human genes:c:cycs|CYCS]]|0.462|
|[[:human genes:t:tamm41|TAMM41]]|0.461|
|[[:human genes:t:tmem261|TMEM261]]|0.461|
|[[:human genes:c:coq7|COQ7]]|0.46|
|[[:human genes:s:ssb|SSB]]|0.46|
|[[:human genes:t:tfb2m|TFB2M]]|0.46|
|[[:human genes:s:ssbp1|SSBP1]]|0.459|
|[[:human genes:h:higd2a|HIGD2A]]|0.459|
|[[:human genes:n:nfu1|NFU1]]|0.458|
|[[:human genes:m:mrps28|MRPS28]]|0.458|
|[[:human genes:c:coq4|COQ4]]|0.458|
|[[:human genes:t:tomm40|TOMM40]]|0.457|
|[[:human genes:d:ddx28|DDX28]]|0.456|
|[[:human genes:m:mrpl46|MRPL46]]|0.456|
|[[:human genes:u:uap1|UAP1]]|0.454|
|[[:human genes:t:trmt10c|TRMT10C]]|0.454|
|[[:human genes:l:lrpprc|LRPPRC]]|0.454|
|[[:human genes:m:mrpl35|MRPL35]]|0.453|
|[[:human genes:c:coq6|COQ6]]|0.453|
|[[:human genes:t:thg1l|THG1L]]|0.453|
|[[:human genes:m:mrpl38|MRPL38]]|0.452|
|[[:human genes:s:sco1|SCO1]]|0.448|
|[[:human genes:m:mtif3|MTIF3]]|0.447|
|[[:human genes:c:cox19|COX19]]|0.444|
|[[:human genes:s:slc25a3|SLC25A3]]|0.443|
|[[:human genes:c:cox20|COX20]]|0.442|
|[[:human genes:u:uhrf1|UHRF1]]|0.442|
|[[:human genes:m:mrpl51|MRPL51]]|0.441|
|[[:human genes:a:alg1|ALG1]]|0.44|
|[[:human genes:p:ppcdc|PPCDC]]|0.44|
|[[:human genes:p:pitrm1|PITRM1]]|0.439|
|[[:human genes:a:atp5e|ATP5E]]|0.439|
|[[:human genes:c:coq5|COQ5]]|0.438|
|[[:human genes:e:eral1|ERAL1]]|0.438|
|[[:human genes:t:ttc4|TTC4]]|0.437|
|[[:human genes:m:mrpl32|MRPL32]]|0.437|
|[[:human genes:g:gars|GARS]]|0.433|
|[[:human genes:m:mcat|MCAT]]|0.432|
|[[:human genes:g:gfer|GFER]]|0.431|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.431|
|[[:human genes:r:rft1|RFT1]]|0.431|
|[[:human genes:s:slc25a52|SLC25A52]]|0.43|
|[[:human genes:t:tomm22|TOMM22]]|0.429|
|[[:human genes:c:clpp|CLPP]]|0.428|
|[[:human genes:p:pmvk|PMVK]]|0.427|
|[[:human genes:r:rpe|RPE]]|0.426|
|[[:human genes:d:ddx39a|DDX39A]]|0.426|
|[[:human genes:a:alg13|ALG13]]|0.425|
|[[:human genes:m:mto1|MTO1]]|0.421|
|[[:human genes:a:atp5f1|ATP5F1]]|0.421|
|[[:human genes:t:taz|TAZ]]|0.42|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.42|
|[[:human genes:c:c11orf57|C11orf57]]|0.419|
|[[:human genes:m:mrpl9|MRPL9]]|0.419|
|[[:human genes:d:dohh|DOHH]]|0.418|
|[[:human genes:n:ndufs5|NDUFS5]]|0.417|
|[[:human genes:m:mrps18b|MRPS18B]]|0.415|
|[[:human genes:a:atp5l|ATP5L]]|0.414|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.413|
|[[:human genes:n:nubpl|NUBPL]]|0.413|
|[[:human genes:r:rfk|RFK]]|0.413|
|[[:human genes:z:zrsr2|ZRSR2]]|0.411|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.411|
|[[:human genes:t:ten1|TEN1]]|0.408|
|[[:human genes:k:kdsr|KDSR]]|0.407|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.406|
|[[:human genes:f:fastkd2|FASTKD2]]|0.406|
|[[:human genes:s:srp14|SRP14]]|0.405|
|[[:human genes:a:alg5|ALG5]]|0.403|
|[[:human genes:n:ndufc1|NDUFC1]]|0.402|
|[[:human genes:p:prkrir|PRKRIR]]|0.401|
|[[:human genes:u:uqcrfs1|UQCRFS1]]|0.401|
|[[:human genes:f:fastkd1|FASTKD1]]|0.4|
|[[:human genes:c:cbx3|CBX3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 154/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|6/26|
|bone|7/26|
|breast|5/30|
|central nervous system|3/49|
|cervix|1/4|
|colorectal|1/17|
|esophagus|7/11|
|fibroblast|0/1|
|gastric|3/14|
|kidney|4/18|
|liver|7/19|
|lung|19/72|
|lymphocyte|3/16|
|ovary|1/25|
|pancreas|5/22|
|peripheral nervous system|2/15|
|plasma cell|1/12|
|prostate|0/1|
|skin|2/20|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|13/22|
|urinary tract|8/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 32
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSD17B10 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>