HSD17B4 [The Human Chemical-Genetic Interaction Map Project]

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======= HSD17B4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSD17B4
  * **<color #00a2e8>Official Name</color>**: hydroxysteroid 17-beta dehydrogenase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3295|3295]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51659|P51659]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSD17B4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSD17B4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids. {ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KR|
|SCP2|
|MaoC dehydratas|
|adh short|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|17-beta-hydroxysteroid dehydrogenase (NAD+) activity|
|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|
|very long-chain fatty-acyl-CoA metabolic process|
|medium-chain fatty-acyl-CoA metabolic process|
|long-chain-enoyl-CoA hydratase activity|
|3-hydroxyacyl-CoA dehydrogenase activity|
|alpha-linolenic acid metabolic process|
|Sertoli cell development|
|isomerase activity|
|fatty acid beta-oxidation using acyl-CoA oxidase|
|Sertoli cell differentiation|
|androgen metabolic process|
|bile acid biosynthetic process|
|very long-chain fatty acid metabolic process|
|estrogen metabolic process|
|bile acid metabolic process|
|fatty-acyl-CoA metabolic process|
|peroxisomal matrix|
|fatty acid beta-oxidation|
|peroxisomal membrane|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|fatty acid oxidation|
|lipid oxidation|
|peroxisome organization|
|fatty acid catabolic process|
|thioester metabolic process|
|acyl-CoA metabolic process|
|unsaturated fatty acid metabolic process|
|peroxisome|
|long-chain fatty acid metabolic process|
|monocarboxylic acid catabolic process|
|cellular hormone metabolic process|
|osteoblast differentiation|
|steroid biosynthetic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|male gonad development|
|development of primary male sexual characteristics|
|male sex differentiation|
|fatty acid derivative metabolic process|
|monocarboxylic acid biosynthetic process|
|organic hydroxy compound biosynthetic process|
|epithelial cell development|
|cellular lipid catabolic process|
|hormone metabolic process|
|lipid modification|
|gonad development|
|development of primary sexual characteristics|
|coenzyme metabolic process|
|steroid metabolic process|
|ossification|
|sex differentiation|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|purine ribonucleotide metabolic process|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|protein targeting|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|reproductive structure development|
|reproductive system development|
|establishment of protein localization to organelle|
|small molecule catabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|protein localization to organelle|
|cellular amide metabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|intracellular protein transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|epithelium development|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cell development|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.29|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.79|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.72|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.81|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14190
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSD17B4 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>