HSP90B1 [The Human Chemical-Genetic Interaction Map Project]

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======= HSP90B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSP90B1
  * **<color #00a2e8>Official Name</color>**: heat shock protein 90 beta family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7184|7184]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14625|P14625]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSP90B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSP90B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191175|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. {ECO:0000250, ECO:0000269|PubMed:18264092}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HATPase c|
|HSP90|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin rod assembly|
|sequestering of calcium ion|
|sarcoplasmic reticulum lumen|
|ATF6-mediated unfolded protein response|
|endoplasmic reticulum chaperone complex|
|endocytic vesicle lumen|
|protein folding in endoplasmic reticulum|
|cellular response to ATP|
|endoplasmic reticulum to cytosol transport|
|retrograde protein transport, ER to cytosol|
|low-density lipoprotein particle receptor binding|
|protein exit from endoplasmic reticulum|
|response to ATP|
|ER-nucleus signaling pathway|
|actin filament bundle assembly|
|actin filament bundle organization|
|cellular response to nutrient|
|ubiquitin-dependent ERAD pathway|
|protein phosphatase binding|
|ERAD pathway|
|toll-like receptor signaling pathway|
|melanosome|
|endoplasmic reticulum unfolded protein response|
|regulation of phosphoprotein phosphatase activity|
|cellular response to unfolded protein|
|pattern recognition receptor signaling pathway|
|unfolded protein binding|
|response to organophosphorus|
|regulation of protein dephosphorylation|
|cellular response to topologically incorrect protein|
|response to purine-containing compound|
|midbody|
|response to unfolded protein|
|maintenance of location|
|regulation of phosphatase activity|
|response to topologically incorrect protein|
|regulation of dephosphorylation|
|response to nutrient|
|protein folding|
|cellular response to nutrient levels|
|innate immune response-activating signal transduction|
|receptor-mediated endocytosis|
|actin filament organization|
|activation of innate immune response|
|response to endoplasmic reticulum stress|
|cellular response to extracellular stimulus|
|endoplasmic reticulum lumen|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|cellular response to external stimulus|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|response to decreased oxygen levels|
|positive regulation of response to biotic stimulus|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|response to oxygen levels|
|cellular response to drug|
|focal adhesion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|regulation of innate immune response|
|supramolecular fiber organization|
|cellular divalent inorganic cation homeostasis|
|positive regulation of defense response|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|response to nutrient levels|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|response to extracellular stimulus|
|modification-dependent protein catabolic process|
|cellular response to organic cyclic compound|
|modification-dependent macromolecule catabolic process|
|endocytosis|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|actin filament-based process|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|import into cell|
|protein catabolic process|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|regulation of defense response|
|regulation of multi-organism process|
|ion homeostasis|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|negative regulation of cell death|
|intracellular protein transport|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to drug|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|chemical homeostasis|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|proteolysis|
|regulation of hydrolase activity|
|RNA binding|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-3.79|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-3.39|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.5|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.43|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.28|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.27|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.26|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.25|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.12|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.12|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.97|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.91|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.89|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.87|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.79|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.76|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.75|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.72|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.7|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.72|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.74|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.78|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.89|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.78|
|[[:results:exp539|42°C R08 exp539]]|2.85|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.52|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|3.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:ldlrap1|LDLRAP1]]|0.506|
|[[:human genes:l:ldlr|LDLR]]|0.44|
|[[:human genes:d:dnajc3|DNAJC3]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 29/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|2/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|5/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6791
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSP90B1 Expression in NALM6 Cells: 10.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>