HSPA13 [The Human Chemical-Genetic Interaction Map Project]

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======= HSPA13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSPA13
  * **<color #00a2e8>Official Name</color>**: heat shock protein family A (Hsp70) member 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6782|6782]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48723|P48723]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSPA13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSPA13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601100|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has peptide-independent ATPase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HSP70|
|MreB Mbl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum chaperone complex|
|ATPase activity, coupled|
|protein folding chaperone|
|misfolded protein binding|
|chaperone cofactor-dependent protein refolding|
|protein refolding|
|de novo posttranslational protein folding|
|de novo protein folding|
|chaperone-mediated protein folding|
|heat shock protein binding|
|cellular response to heat|
|ubiquitin-dependent ERAD pathway|
|ERAD pathway|
|endoplasmic reticulum unfolded protein response|
|response to heat|
|cellular response to unfolded protein|
|unfolded protein binding|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|response to temperature stimulus|
|response to topologically incorrect protein|
|protein folding|
|ATPase activity|
|response to endoplasmic reticulum stress|
|endoplasmic reticulum lumen|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|cellular macromolecule catabolic process|
|response to organonitrogen compound|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|response to abiotic stimulus|
|proteolysis|
|ATP binding|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.34|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.13|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.04|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.02|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.96|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.78|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.7|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.72|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.72|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.79|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.95|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.38|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13282
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSPA13 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>