HSPA2 [The Human Chemical-Genetic Interaction Map Project]

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======= HSPA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSPA2
  * **<color #00a2e8>Official Name</color>**: heat shock protein family A (Hsp70) member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3306|3306]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54652|P54652]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSPA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSPA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/140560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HSP70|
|MreB Mbl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptonemal complex disassembly|
|glycolipid binding|
|positive regulation of ATPase-coupled calcium transmembrane transporter activity|
|CatSper complex|
|meiotic spindle|
|regulation of ATPase-coupled calcium transmembrane transporter activity|
|negative regulation of inclusion body assembly|
|male germ cell nucleus|
|regulation of inclusion body assembly|
|ATPase activity, coupled|
|protein folding chaperone|
|synaptonemal complex organization|
|male meiosis I|
|synaptonemal complex|
|misfolded protein binding|
|positive regulation of G2/M transition of mitotic cell cycle|
|positive regulation of cell cycle G2/M phase transition|
|chaperone cofactor-dependent protein refolding|
|disordered domain specific binding|
|de novo posttranslational protein folding|
|protein refolding|
|positive regulation of calcium ion transmembrane transporter activity|
|de novo protein folding|
|tau protein binding|
|male meiotic nuclear division|
|response to cold|
|positive regulation of ATPase activity|
|heat shock protein binding|
|chaperone-mediated protein folding|
|positive regulation of calcium ion transmembrane transport|
|cellular response to heat|
|positive regulation of mitotic cell cycle phase transition|
|regulation of ATPase activity|
|regulation of calcium ion transmembrane transporter activity|
|positive regulation of cell cycle phase transition|
|chaperone binding|
|positive regulation of ion transmembrane transporter activity|
|response to heat|
|meiosis I|
|positive regulation of transporter activity|
|meiosis I cell cycle process|
|positive regulation of calcium ion transport|
|cellular response to unfolded protein|
|unfolded protein binding|
|positive regulation of cation transmembrane transport|
|blood microparticle|
|regulation of calcium ion transmembrane transport|
|cellular response to topologically incorrect protein|
|positive regulation of mitotic cell cycle|
|spermatid development|
|meiotic nuclear division|
|positive regulation of ion transmembrane transport|
|spermatid differentiation|
|response to unfolded protein|
|meiotic cell cycle process|
|response to temperature stimulus|
|response to topologically incorrect protein|
|regulation of G2/M transition of mitotic cell cycle|
|positive regulation of transmembrane transport|
|regulation of cell cycle G2/M phase transition|
|meiotic cell cycle|
|protein folding|
|ATPase activity|
|regulation of calcium ion transport|
|germ cell development|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|nuclear division|
|positive regulation of cell cycle process|
|organelle fission|
|regulation of cation transmembrane transport|
|enzyme binding|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of cell cycle|
|regulation of metal ion transport|
|cellular component disassembly|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|regulation of ion transmembrane transport|
|spermatogenesis|
|regulation of transmembrane transport|
|male gamete generation|
|cell surface|
|regulation of mitotic cell cycle|
|developmental process involved in reproduction|
|gamete generation|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|multi-organism reproductive process|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|chromosome organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|cell cycle|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cell development|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11052
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSPA2 Expression in NALM6 Cells: 3.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>