HSPH1 [The Human Chemical-Genetic Interaction Map Project]

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======= HSPH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSPH1
  * **<color #00a2e8>Official Name</color>**: heat shock protein family H (Hsp110) member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10808|10808]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92598|Q92598]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSPH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSPH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610703|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MreB Mbl|
|HSP70|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of MHC class I biosynthetic process|
|regulation of MHC class I biosynthetic process|
|positive regulation of NK T cell activation|
|adenyl-nucleotide exchange factor activity|
|regulation of NK T cell activation|
|endocytic vesicle lumen|
|chaperone cofactor-dependent protein refolding|
|de novo posttranslational protein folding|
|alpha-tubulin binding|
|de novo protein folding|
|chaperone-mediated protein folding|
|positive regulation of alpha-beta T cell activation|
|regulation of cellular response to heat|
|regulation of alpha-beta T cell activation|
|response to unfolded protein|
|response to topologically incorrect protein|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|protein folding|
|receptor-mediated endocytosis|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|microtubule|
|regulation of T cell activation|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of lymphocyte activation|
|endocytosis|
|protein-containing complex|
|regulation of leukocyte activation|
|regulation of cell activation|
|import into cell|
|regulation of cell adhesion|
|regulation of cellular response to stress|
|positive regulation of immune system process|
|regulation of response to stress|
|ATP binding|
|regulation of immune system process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.08|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.06|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.92|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.72|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.73|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.97|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.98|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.01|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.06|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.08|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13315
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSPH1 Expression in NALM6 Cells: 8.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>