HTATSF1 [The Human Chemical-Genetic Interaction Map Project]

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======= HTATSF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HTATSF1
  * **<color #00a2e8>Official Name</color>**: HIV-1 Tat specific factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27336|27336]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43719|O43719]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HTATSF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HTATSF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300346|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type spliceosomal complex|
|U2 snRNP|
|viral genome replication|
|regulation of DNA-templated transcription, elongation|
|viral life cycle|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.34|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.99|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.99|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.97|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.75|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:terf1|TERF1]]|0.449|
|[[:human genes:t:tfip11|TFIP11]]|0.436|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.432|
|[[:human genes:s:sf3a2|SF3A2]]|0.431|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.42|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.404|
|[[:human genes:p:psma6|PSMA6]]|0.404|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.403|
|[[:human genes:k:kctd17|KCTD17]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 515/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|22/26|
|bone|23/26|
|breast|19/30|
|central nervous system|32/49|
|cervix|4/4|
|colorectal|12/17|
|esophagus|7/11|
|fibroblast|1/1|
|gastric|8/14|
|kidney|12/18|
|liver|13/19|
|lung|52/72|
|lymphocyte|14/16|
|ovary|19/25|
|pancreas|18/22|
|peripheral nervous system|13/15|
|plasma cell|10/12|
|prostate|1/1|
|skin|18/20|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|17/28|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 459
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HTATSF1 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>