HTR2B [The Human Chemical-Genetic Interaction Map Project]

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======= HTR2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HTR2B
  * **<color #00a2e8>Official Name</color>**: 5-hydroxytryptamine receptor 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3357|3357]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41595|P41595]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HTR2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HTR2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601122|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538). Signaling activates a phosphatidylinositol- calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity). {ECO:0000250|UniProtKB:P30994, ECO:0000250|UniProtKB:Q02152, ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:21179162, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856, ECO:0000269|PubMed:8882600}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intestine smooth muscle contraction|
|cellular response to temperature stimulus|
|gastro-intestinal system smooth muscle contraction|
|positive regulation of phosphatidylinositol biosynthetic process|
|regulation of phosphatidylinositol biosynthetic process|
|serotonin binding|
|positive regulation of phospholipid biosynthetic process|
|G protein-coupled receptor internalization|
|protein kinase C signaling|
|regulation of phospholipid biosynthetic process|
|phasic smooth muscle contraction|
|negative adaptation of signaling pathway|
|desensitization of G protein-coupled receptor signaling pathway|
|adaptation of signaling pathway|
|positive regulation of nitric-oxide synthase activity|
|G-protein alpha-subunit binding|
|cGMP-mediated signaling|
|positive regulation of monooxygenase activity|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|ERK1 and ERK2 cascade|
|cardiac muscle hypertrophy|
|striated muscle hypertrophy|
|activation of phospholipase C activity|
|vasoconstriction|
|muscle hypertrophy|
|phosphatidylinositol 3-kinase signaling|
|G protein-coupled serotonin receptor activity|
|G protein-coupled serotonin receptor signaling pathway|
|neurotransmitter receptor activity|
|negative regulation of blood vessel diameter|
|serotonin receptor signaling pathway|
|positive regulation of phospholipase C activity|
|regulation of nitric-oxide synthase activity|
|regulation of phospholipase C activity|
|negative regulation of G protein-coupled receptor signaling pathway|
|positive regulation of phospholipid metabolic process|
|smooth muscle contraction|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|neural crest cell migration|
|release of sequestered calcium ion into cytosol|
|drug binding|
|negative regulation of sequestering of calcium ion|
|positive regulation of phospholipase activity|
|receptor internalization|
|calcium ion transmembrane import into cytosol|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|phosphatidylinositol-mediated signaling|
|regulation of behavior|
|calcium ion transport into cytosol|
|inositol lipid-mediated signaling|
|positive regulation of lipid biosynthetic process|
|neural crest cell development|
|stem cell development|
|mesenchymal cell development|
|negative regulation of autophagy|
|regulation of phospholipid metabolic process|
|cellular response to dopamine|
|positive regulation of cell division|
|response to dopamine|
|cytosolic calcium ion transport|
|neural crest cell differentiation|
|signal transduction involved in cellular response to ammonium ion|
|positive regulation of endothelial cell proliferation|
|regulation of oxidoreductase activity|
|regulation of lipase activity|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|receptor metabolic process|
|response to catecholamine|
|response to monoamine|
|regulation of sequestering of calcium ion|
|regulation of endothelial cell proliferation|
|cellular response to ammonium ion|
|positive regulation of cytokine secretion|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|positive regulation of lipid metabolic process|
|regulation of G protein-coupled receptor signaling pathway|
|calcium-mediated signaling|
|mesenchymal cell differentiation|
|stem cell differentiation|
|regulation of cell division|
|vascular process in circulatory system|
|ameboidal-type cell migration|
|cyclic-nucleotide-mediated signaling|
|response to temperature stimulus|
|response to ammonium ion|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of lipid biosynthetic process|
|positive regulation of epithelial cell proliferation|
|calcium ion transmembrane transport|
|regulation of cytokine secretion|
|positive regulation of ERK1 and ERK2 cascade|
|mesenchyme development|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|receptor-mediated endocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|calcium ion transport|
|muscle contraction|
|heart morphogenesis|
|negative regulation of cellular catabolic process|
|positive regulation of MAP kinase activity|
|synapse|
|positive regulation of protein secretion|
|GTPase activator activity|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|negative regulation of catabolic process|
|regulation of cytosolic calcium ion concentration|
|regulation of autophagy|
|regulation of epithelial cell proliferation|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|MAPK cascade|
|blood circulation|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|circulatory system process|
|positive regulation of secretion by cell|
|cellular response to drug|
|positive regulation of GTPase activity|
|dendrite|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of GTPase activity|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|heart development|
|positive regulation of protein kinase activity|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|cell junction|
|endocytosis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|embryonic morphogenesis|
|behavior|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|import into cell|
|regulation of cytokine production|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|cation transport|
|regulation of cellular catabolic process|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|ion transmembrane transport|
|animal organ morphogenesis|
|cell migration|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|transmembrane transport|
|phosphorylation|
|locomotion|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.91|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.645|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15069
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HTR2B Expression in NALM6 Cells: -1.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>