HYAL2 [The Human Chemical-Genetic Interaction Map Project]

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======= HYAL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HYAL2
  * **<color #00a2e8>Official Name</color>**: hyaluronidase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8692|8692]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12891|Q12891]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HYAL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HYAL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603551|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. {ECO:0000269|PubMed:11296287, ECO:0000269|PubMed:12676986, ECO:0000269|PubMed:9712871}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 56|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|receptor signaling protein tyrosine kinase inhibitor activity|
|hyaluronoglucuronidase activity|
|transformation of host cell by virus|
|renal water absorption|
|renal water transport|
|negative regulation of fibroblast migration|
|multi-organism membrane fusion|
|membrane fusion involved in viral entry into host cell|
|fusion of virus membrane with host plasma membrane|
|hyalurononglucosaminidase activity|
|cellular response to UV-B|
|monocyte activation|
|multicellular organismal iron ion homeostasis|
|multi-organism membrane organization|
|positive regulation of urine volume|
|renal absorption|
|positive regulation of interleukin-8 secretion|
|hyaluronan catabolic process|
|response to UV-B|
|anchored component of external side of plasma membrane|
|water transport|
|regulation of urine volume|
|transforming growth factor beta binding|
|multi-organism cellular process|
|hyaluronic acid binding|
|regulation of interleukin-8 secretion|
|fluid transport|
|negative regulation of protein tyrosine kinase activity|
|regulation of fibroblast migration|
|positive regulation of interleukin-6 secretion|
|hyaluronan metabolic process|
|modulation by virus of host morphology or physiology|
|anchored component of plasma membrane|
|multicellular organism aging|
|renal water homeostasis|
|positive regulation of protein import into nucleus|
|positive regulation of protein import|
|modification by symbiont of host morphology or physiology|
|negative regulation of protein kinase B signaling|
|positive regulation of extrinsic apoptotic signaling pathway|
|positive regulation of interleukin-8 production|
|negative regulation of peptidyl-tyrosine phosphorylation|
|regulation of protein import into nucleus|
|receptor tyrosine kinase binding|
|endocytic vesicle|
|regulation of protein import|
|glycosaminoglycan catabolic process|
|microvillus|
|positive regulation of nucleocytoplasmic transport|
|aminoglycan catabolic process|
|multicellular organismal water homeostasis|
|regulation of interleukin-8 production|
|RNA polymerase II transcription factor complex|
|water homeostasis|
|positive regulation of protein localization to nucleus|
|negative regulation of MAP kinase activity|
|virus receptor activity|
|iron ion homeostasis|
|cellular response to UV|
|hematopoietic progenitor cell differentiation|
|regulation of protein tyrosine kinase activity|
|viral entry into host cell|
|positive regulation of interleukin-6 production|
|entry into host|
|entry into host cell|
|regulation of nucleocytoplasmic transport|
|mucopolysaccharide metabolic process|
|cellular response to fibroblast growth factor stimulus|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|renal system process|
|cellular response to light stimulus|
|response to fibroblast growth factor|
|regulation of protein localization to nucleus|
|membrane fusion|
|transition metal ion homeostasis|
|negative regulation of protein serine/threonine kinase activity|
|positive regulation of cytokine secretion|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|response to UV|
|positive regulation of intracellular protein transport|
|regulation of extrinsic apoptotic signaling pathway|
|cellular response to transforming growth factor beta stimulus|
|modification of morphology or physiology of other organism|
|glycosaminoglycan metabolic process|
|interaction with host|
|response to transforming growth factor beta|
|aminoglycan metabolic process|
|negative regulation of MAPK cascade|
|cartilage development|
|positive regulation of apoptotic signaling pathway|
|cellular response to interleukin-1|
|cellular response to radiation|
|negative regulation of cell growth|
|defense response to virus|
|carbohydrate derivative catabolic process|
|response to reactive oxygen species|
|response to interleukin-1|
|viral life cycle|
|regulation of cytokine secretion|
|positive regulation of intracellular transport|
|regulation of protein kinase B signaling|
|connective tissue development|
|negative regulation of protein kinase activity|
|membrane raft|
|regulation of intracellular protein transport|
|skeletal system morphogenesis|
|cellular response to tumor necrosis factor|
|negative regulation of growth|
|negative regulation of kinase activity|
|lysosome|
|cytoplasmic vesicle|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell migration|
|response to tumor necrosis factor|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|kidney development|
|positive regulation of protein secretion|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|aging|
|response to virus|
|transcription coactivator activity|
|renal system development|
|positive regulation of peptide secretion|
|response to antibiotic|
|response to light stimulus|
|negative regulation of cellular component movement|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|urogenital system development|
|apical plasma membrane|
|negative regulation of locomotion|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|regulation of inflammatory response|
|regulation of MAP kinase activity|
|enzyme binding|
|regulation of intracellular transport|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|negative regulation of protein phosphorylation|
|regulation of cell growth|
|positive regulation of protein transport|
|positive regulation of secretion|
|small molecule catabolic process|
|response to radiation|
|negative regulation of phosphorylation|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|carbohydrate metabolic process|
|skeletal system development|
|regulation of peptide secretion|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|response to growth factor|
|regulation of cellular protein localization|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|cell surface|
|Golgi membrane|
|metal ion homeostasis|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|regulation of growth|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|viral process|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|symbiotic process|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|interspecies interaction between organisms|
|regulation of cell migration|
|membrane organization|
|regulation of kinase activity|
|carboxylic acid metabolic process|
|regulation of cell motility|
|regulation of cellular localization|
|leukocyte activation|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|organic acid metabolic process|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of molecular function|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12505
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HYAL2 Expression in NALM6 Cells: 4.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>