HYPK [The Human Chemical-Genetic Interaction Map Project]

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======= HYPK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HYPK
  * **<color #00a2e8>Official Name</color>**: huntingtin interacting protein K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25764|25764]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX55|Q9NX55]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HYPK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HYPK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612784|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation. {ECO:0000269|PubMed:17947297, ECO:0000269|PubMed:20154145}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein N-terminus binding|
|microtubule cytoskeleton|
|protein stabilization|
|regulation of protein stability|
|protein-containing complex|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.76|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.77|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.81|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.83|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.91|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.91|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.94|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.23|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 226/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|2/28|
|bone|5/26|
|breast|9/33|
|central nervous system|19/56|
|cervix|1/4|
|colorectal|11/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|10/21|
|liver|6/20|
|lung|24/75|
|lymphocyte|2/16|
|ovary|15/26|
|pancreas|2/24|
|peripheral nervous system|4/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|10/22|
|urinary tract|16/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2040
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HYPK Expression in NALM6 Cells: 5.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>