IARS2 [The Human Chemical-Genetic Interaction Map Project]

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======= IARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IARS2
  * **<color #00a2e8>Official Name</color>**: isoleucyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55699|55699]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NSE4|Q9NSE4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612801|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 1|
|Anticodon 1|
|tRNA-synt 1g|
|zf-FPG IleRS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|isoleucyl-tRNA aminoacylation|
|isoleucine-tRNA ligase activity|
|aminoacyl-tRNA metabolism involved in translational fidelity|
|aminoacyl-tRNA editing activity|
|regulation of translational fidelity|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|mitochondrial translation|
|mitochondrial gene expression|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.73|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.7|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.74|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.77|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.78|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.81|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.83|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.89|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.91|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.616|
|[[:human genes:e:eprs|EPRS]]|0.448|
|[[:human genes:a:alg14|ALG14]]|0.432|
|[[:human genes:n:nars|NARS]]|0.428|
|[[:human genes:g:gmppb|GMPPB]]|0.428|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 561/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|25/28|
|bone|16/26|
|breast|23/33|
|central nervous system|40/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|10/21|
|liver|17/20|
|lung|65/75|
|lymphocyte|13/16|
|ovary|21/26|
|pancreas|18/24|
|peripheral nervous system|13/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|14/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|25/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 678
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IARS2 Expression in NALM6 Cells: 7.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>