IDH2 [The Human Chemical-Genetic Interaction Map Project]

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======= IDH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IDH2
  * **<color #00a2e8>Official Name</color>**: isocitrate dehydrogenase (NADP(+)) 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3418|3418]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48735|P48735]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IDH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IDH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147650|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Iso dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of matrix metallopeptidase secretion|
|glyoxylate cycle|
|regulation of matrix metallopeptidase secretion|
|isocitrate dehydrogenase (NADP+) activity|
|NADP biosynthetic process|
|negative regulation of glial cell migration|
|isocitrate metabolic process|
|glyoxylate metabolic process|
|negative regulation of glial cell proliferation|
|tricarboxylic acid metabolic process|
|regulation of glial cell migration|
|2-oxoglutarate metabolic process|
|NADP metabolic process|
|regulation of glial cell proliferation|
|pyridine nucleotide biosynthetic process|
|nicotinamide nucleotide biosynthetic process|
|pyridine nucleotide metabolic process|
|nicotinamide nucleotide metabolic process|
|tricarboxylic acid cycle|
|pyridine-containing compound biosynthetic process|
|NAD binding|
|negative regulation of gliogenesis|
|pyridine-containing compound metabolic process|
|oxidoreduction coenzyme metabolic process|
|cellular aldehyde metabolic process|
|aerobic respiration|
|dicarboxylic acid metabolic process|
|peroxisome|
|regulation of gliogenesis|
|secondary alcohol metabolic process|
|negative regulation of protein secretion|
|coenzyme biosynthetic process|
|negative regulation of peptide secretion|
|cellular respiration|
|cellular carbohydrate metabolic process|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|cofactor biosynthetic process|
|magnesium ion binding|
|negative regulation of secretion|
|energy derivation by oxidation of organic compounds|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|alcohol metabolic process|
|negative regulation of locomotion|
|negative regulation of cell development|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|regulation of protein secretion|
|carbohydrate metabolic process|
|negative regulation of transport|
|regulation of peptide secretion|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|negative regulation of cell population proliferation|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cell migration|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|oxidation-reduction process|
|regulation of locomotion|
|regulation of cellular component movement|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of protein localization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.13|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7762
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IDH2 Expression in NALM6 Cells: 8.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>