IDO1 [The Human Chemical-Genetic Interaction Map Project]

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======= IDO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IDO1
  * **<color #00a2e8>Official Name</color>**: indoleamine 2,3-dioxygenase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3620|3620]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14902|P14902]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IDO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IDO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147435|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). {ECO:0000269|PubMed:14502282, ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:23103127, ECO:0000303|PubMed:25157255, ECO:0000303|PubMed:25691885}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IDO|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|swimming behavior|
|kynurenic acid biosynthetic process|
|kynurenic acid metabolic process|
|indoleamine 2,3-dioxygenase activity|
|tryptophan 2,3-dioxygenase activity|
|cytokine production involved in inflammatory response|
|positive regulation of chronic inflammatory response|
|smooth muscle contractile fiber|
|stereocilium bundle|
|tryptophan catabolic process to kynurenine|
|positive regulation of T cell tolerance induction|
|de novo NAD biosynthetic process from tryptophan|
|de novo NAD biosynthetic process|
|regulation of T cell tolerance induction|
|positive regulation of tolerance induction|
|regulation of chronic inflammatory response|
|tryptophan catabolic process|
|indole-containing compound catabolic process|
|indolalkylamine catabolic process|
|kynurenine metabolic process|
|tryptophan metabolic process|
|positive regulation of T cell apoptotic process|
|production of molecular mediator involved in inflammatory response|
|regulation of tolerance induction|
|positive regulation of type 2 immune response|
|indolalkylamine metabolic process|
|negative regulation of interleukin-10 production|
|negative regulation of T cell apoptotic process|
|positive regulation of lymphocyte apoptotic process|
|cellular biogenic amine catabolic process|
|amine catabolic process|
|indole-containing compound metabolic process|
|benzene-containing compound metabolic process|
|positive regulation of leukocyte apoptotic process|
|aromatic amino acid family catabolic process|
|negative regulation of lymphocyte apoptotic process|
|NAD biosynthetic process|
|regulation of type 2 immune response|
|nicotinamide nucleotide biosynthetic process|
|pyridine nucleotide biosynthetic process|
|nicotinamide nucleotide metabolic process|
|regulation of T cell apoptotic process|
|pyridine nucleotide metabolic process|
|positive regulation of interleukin-12 production|
|regulation of activated T cell proliferation|
|pyridine-containing compound biosynthetic process|
|aromatic amino acid family metabolic process|
|pyridine-containing compound metabolic process|
|negative regulation of leukocyte apoptotic process|
|oxidoreduction coenzyme metabolic process|
|regulation of interleukin-10 production|
|regulation of lymphocyte apoptotic process|
|regulation of interleukin-12 production|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|negative regulation of T cell proliferation|
|amine metabolic process|
|multicellular organismal response to stress|
|cellular ketone metabolic process|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|electron transfer activity|
|negative regulation of leukocyte proliferation|
|regulation of leukocyte apoptotic process|
|alpha-amino acid catabolic process|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|cellular amino acid catabolic process|
|coenzyme biosynthetic process|
|positive regulation of inflammatory response|
|heme binding|
|negative regulation of lymphocyte activation|
|cytokine production|
|regulation of T cell proliferation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|female pregnancy|
|electron transport chain|
|monocarboxylic acid biosynthetic process|
|locomotory behavior|
|negative regulation of cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|alpha-amino acid metabolic process|
|multi-multicellular organism process|
|cofactor biosynthetic process|
|regulation of leukocyte proliferation|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|regulation of cell-cell adhesion|
|generation of precursor metabolites and energy|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|positive regulation of cytokine production|
|nucleoside phosphate metabolic process|
|positive regulation of defense response|
|organic cyclic compound catabolic process|
|inflammatory response|
|drug metabolic process|
|regulation of lymphocyte activation|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|behavior|
|small molecule biosynthetic process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of defense response|
|response to lipid|
|positive regulation of immune response|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|negative regulation of cell death|
|multi-organism reproductive process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15137
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IDO1 Expression in NALM6 Cells: -3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>