IDO2 [The Human Chemical-Genetic Interaction Map Project]

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======= IDO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IDO2
  * **<color #00a2e8>Official Name</color>**: indoleamine 2,3-dioxygenase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=169355|169355]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZQW0|Q6ZQW0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IDO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IDO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612129|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885). {ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:25691885}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IDO|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|indoleamine 2,3-dioxygenase activity|
|tryptophan 2,3-dioxygenase activity|
|tryptophan catabolic process to kynurenine|
|de novo NAD biosynthetic process|
|de novo NAD biosynthetic process from tryptophan|
|indolalkylamine catabolic process|
|indole-containing compound catabolic process|
|tryptophan catabolic process|
|kynurenine metabolic process|
|tryptophan metabolic process|
|indolalkylamine metabolic process|
|amine catabolic process|
|cellular biogenic amine catabolic process|
|indole-containing compound metabolic process|
|benzene-containing compound metabolic process|
|aromatic amino acid family catabolic process|
|NAD biosynthetic process|
|pyridine nucleotide biosynthetic process|
|nicotinamide nucleotide biosynthetic process|
|pyridine nucleotide metabolic process|
|nicotinamide nucleotide metabolic process|
|pyridine-containing compound biosynthetic process|
|aromatic amino acid family metabolic process|
|pyridine-containing compound metabolic process|
|oxidoreduction coenzyme metabolic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|amine metabolic process|
|cellular ketone metabolic process|
|alpha-amino acid catabolic process|
|cellular amino acid catabolic process|
|coenzyme biosynthetic process|
|heme binding|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|cellular amino acid metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10993
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IDO2 Expression in NALM6 Cells: 1.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>