IFI16 [The Human Chemical-Genetic Interaction Map Project]

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======= IFI16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFI16
  * **<color #00a2e8>Official Name</color>**: interferon gamma inducible protein 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3428|3428]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16666|Q16666]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFI16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFI16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147586|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAAD DAPIN|
|HIN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of cysteine-type endopeptidase activity|
|mononuclear cell differentiation|
|monocyte differentiation|
|cellular response to interferon-beta|
|response to interferon-beta|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|zymogen activation|
|cellular response to glucose starvation|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|positive regulation of interleukin-1 beta production|
|negative regulation of DNA binding|
|negative regulation of innate immune response|
|negative regulation of viral genome replication|
|positive regulation of interleukin-1 production|
|cellular response to ionizing radiation|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of type I interferon production|
|regulation of interleukin-1 beta production|
|negative regulation of viral life cycle|
|negative regulation of cysteine-type endopeptidase activity|
|negative regulation of response to biotic stimulus|
|regulation of viral genome replication|
|regulation of interleukin-1 production|
|negative regulation of viral process|
|double-stranded DNA binding|
|myeloid leukocyte differentiation|
|signal transduction by p53 class mediator|
|regulation of DNA binding|
|regulation of type I interferon production|
|regulation of viral life cycle|
|intrinsic apoptotic signaling pathway|
|negative regulation of immune response|
|response to ionizing radiation|
|cellular response to starvation|
|positive regulation of cysteine-type endopeptidase activity|
|protein processing|
|negative regulation of binding|
|positive regulation of endopeptidase activity|
|cellular response to radiation|
|defense response to virus|
|positive regulation of peptidase activity|
|response to starvation|
|regulation of viral process|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|myeloid cell differentiation|
|protein maturation|
|cellular response to nutrient levels|
|regulation of gene expression, epigenetic|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|negative regulation of peptidase activity|
|activation of innate immune response|
|autophagy|
|process utilizing autophagic mechanism|
|cellular response to extracellular stimulus|
|response to virus|
|apoptotic signaling pathway|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|leukocyte differentiation|
|regulation of autophagy|
|transcription factor binding|
|cellular response to external stimulus|
|positive regulation of innate immune response|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|regulation of binding|
|nuclear speck|
|regulation of endopeptidase activity|
|response to radiation|
|negative regulation of immune system process|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|positive regulation of defense response|
|inflammatory response|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|response to extracellular stimulus|
|cell population proliferation|
|hemopoiesis|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|immune system development|
|regulation of cytokine production|
|regulation of proteolysis|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|apoptotic process|
|defense response to other organism|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|cellular catabolic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.28|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.93|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.79|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.75|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18722
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFI16 Expression in NALM6 Cells: 6.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>