IFI27 [The Human Chemical-Genetic Interaction Map Project]

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======= IFI27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFI27
  * **<color #00a2e8>Official Name</color>**: interferon alpha inducible protein 27
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3429|3429]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40305|P40305]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFI27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFI27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600009|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. {ECO:0000269|PubMed:18330707}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ifi-6-16|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modulation by host of viral genome replication|
|lamin binding|
|modulation by host of viral process|
|regulation of protein export from nucleus|
|nuclear inner membrane|
|RNA polymerase II activating transcription factor binding|
|protein K48-linked ubiquitination|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|response to type I interferon|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|regulation of viral genome replication|
|extrinsic apoptotic signaling pathway|
|mitochondrial membrane|
|regulation of nucleocytoplasmic transport|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of viral life cycle|
|modification of morphology or physiology of other organism|
|mitochondrial outer membrane|
|nuclear envelope|
|defense response to virus|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of intracellular protein transport|
|response to virus|
|apoptotic signaling pathway|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|viral process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|molecular function|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|apoptotic process|
|endoplasmic reticulum membrane|
|defense response to other organism|
|protein modification by small protein conjugation or removal|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell death|
|immune effector process|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13156
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFI27 Expression in NALM6 Cells: 1.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>