IFIT1 [The Human Chemical-Genetic Interaction Map Project]

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======= IFIT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFIT1
  * **<color #00a2e8>Official Name</color>**: interferon induced protein with tetratricopeptide repeats 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3434|3434]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09914|P09914]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFIT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFIT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147690|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:19416887, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular transport of viral protein in host cell|
|symbiont intracellular protein transport in host|
|intracellular protein transport in other organism involved in symbiotic interaction|
|negative regulation of helicase activity|
|multi-organism intracellular transport|
|multi-organism cellular localization|
|regulation by virus of viral protein levels in host cell|
|regulation of helicase activity|
|cellular response to exogenous dsRNA|
|negative regulation of ATPase activity|
|cellular response to dsRNA|
|positive regulation of viral genome replication|
|response to exogenous dsRNA|
|response to dsRNA|
|host cell|
|negative regulation of viral genome replication|
|positive regulation of viral life cycle|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|multi-organism transport|
|multi-organism localization|
|response to type I interferon|
|regulation of defense response to virus|
|negative regulation of viral life cycle|
|regulation of ATPase activity|
|regulation of viral genome replication|
|negative regulation of viral process|
|negative regulation of protein binding|
|positive regulation of viral process|
|regulation of viral life cycle|
|interaction with host|
|negative regulation of binding|
|defense response to virus|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of protein binding|
|regulation of symbiosis, encompassing mutualism through parasitism|
|response to virus|
|regulation of binding|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|cellular response to organic cyclic compound|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|viral process|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|response to organic cyclic compound|
|defense response to other organism|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|regulation of immune system process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.83|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.79|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.87|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11698
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFIT1 Expression in NALM6 Cells: 3.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>