IFNB1 [The Human Chemical-Genetic Interaction Map Project]

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======= IFNB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFNB1
  * **<color #00a2e8>Official Name</color>**: interferon beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3456|3456]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01574|P01574]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFNB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFNB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has antiviral, antibacterial and anticancer activities.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Interferon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chloramphenicol O-acetyltransferase activity|
|negative regulation of T-helper 2 cell cytokine production|
|regulation of MHC class I biosynthetic process|
|negative regulation of T cell cytokine production|
|regulation of T-helper 2 cell cytokine production|
|negative regulation of type 2 immune response|
|type I interferon receptor binding|
|cellular response to exogenous dsRNA|
|negative regulation of T cell mediated immunity|
|positive regulation of peptidyl-serine phosphorylation of STAT protein|
|cellular response to interferon-beta|
|regulation of peptidyl-serine phosphorylation of STAT protein|
|cellular response to dsRNA|
|natural killer cell activation involved in immune response|
|negative regulation of cytokine production involved in immune response|
|response to interferon-beta|
|regulation of type 2 immune response|
|regulation of T cell cytokine production|
|negative regulation of production of molecular mediator of immune response|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|B cell proliferation|
|negative regulation of T cell differentiation|
|B cell activation involved in immune response|
|negative regulation of adaptive immune response|
|response to exogenous dsRNA|
|negative regulation of leukocyte mediated immunity|
|response to dsRNA|
|negative regulation of lymphocyte differentiation|
|natural killer cell activation|
|negative regulation of viral genome replication|
|T cell activation involved in immune response|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|regulation of T cell mediated immunity|
|response to type I interferon|
|negative regulation of viral life cycle|
|lymphocyte proliferation|
|regulation of cytokine production involved in immune response|
|mononuclear cell proliferation|
|regulation of viral genome replication|
|negative regulation of viral process|
|leukocyte proliferation|
|negative regulation of leukocyte differentiation|
|positive regulation of peptidyl-serine phosphorylation|
|B cell differentiation|
|negative regulation of T cell activation|
|lymphocyte activation involved in immune response|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|negative regulation of hemopoiesis|
|regulation of peptidyl-serine phosphorylation|
|regulation of T cell differentiation|
|regulation of production of molecular mediator of immune response|
|regulation of viral life cycle|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|B cell activation|
|regulation of adaptive immune response|
|regulation of lymphocyte differentiation|
|cytokine activity|
|negative regulation of leukocyte activation|
|positive regulation of apoptotic signaling pathway|
|negative regulation of cell-cell adhesion|
|defense response to virus|
|negative regulation of cell activation|
|regulation of leukocyte mediated immunity|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|T cell activation|
|lymphocyte differentiation|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|response to virus|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|regulation of T cell activation|
|leukocyte differentiation|
|positive regulation of innate immune response|
|humoral immune response|
|positive regulation of response to biotic stimulus|
|lymphocyte activation|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|wound healing|
|regulation of body fluid levels|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|cellular response to organic cyclic compound|
|cell population proliferation|
|hemopoiesis|
|response to wounding|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|response to organic cyclic compound|
|leukocyte activation|
|negative regulation of developmental process|
|defense response to other organism|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18593
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFNB1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>