IFNW1 [The Human Chemical-Genetic Interaction Map Project]

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======= IFNW1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFNW1
  * **<color #00a2e8>Official Name</color>**: interferon omega 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3467|3467]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05000|P05000]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFNW1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFNW1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147553|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Interferon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytokine receptor binding|
|type I interferon receptor binding|
|positive regulation of peptidyl-serine phosphorylation of STAT protein|
|regulation of peptidyl-serine phosphorylation of STAT protein|
|natural killer cell activation involved in immune response|
|B cell proliferation|
|response to exogenous dsRNA|
|response to dsRNA|
|natural killer cell activation|
|T cell activation involved in immune response|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|leukocyte proliferation|
|positive regulation of peptidyl-serine phosphorylation|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|regulation of peptidyl-serine phosphorylation|
|cell cycle arrest|
|B cell activation|
|cytokine activity|
|defense response to virus|
|T cell activation|
|lymphocyte differentiation|
|response to virus|
|leukocyte differentiation|
|humoral immune response|
|lymphocyte activation|
|cell population proliferation|
|hemopoiesis|
|negative regulation of cell cycle|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|cytokine-mediated signaling pathway|
|response to organic cyclic compound|
|leukocyte activation|
|defense response to other organism|
|cell cycle process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|cell cycle|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.01|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.87|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.75|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.75|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.78|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.89|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15273
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFNW1 Expression in NALM6 Cells: -0.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>