IGF2R [The Human Chemical-Genetic Interaction Map Project]

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======= IGF2R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IGF2R
  * **<color #00a2e8>Official Name</color>**: insulin like growth factor 2 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3482|3482]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11717|P11717]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IGF2R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IGF2R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. {ECO:0000269|PubMed:10900005}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CIMR|
|fn2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|insulin-like growth factor-activated receptor activity|
|clathrin coat|
|insulin-like growth factor II binding|
|nuclear envelope lumen|
|insulin-like growth factor receptor signaling pathway|
|trans-Golgi network transport vesicle|
|positive regulation by host of viral process|
|insulin-like growth factor binding|
|mannose binding|
|G-protein alpha-subunit binding|
|retinoic acid binding|
|modulation by host of viral process|
|phosphoprotein binding|
|clathrin-coated vesicle membrane|
|endocytic vesicle|
|modification by host of symbiont morphology or physiology|
|animal organ regeneration|
|interaction with symbiont|
|post-embryonic development|
|transport vesicle|
|trans-Golgi network membrane|
|secretory granule membrane|
|lysosomal transport|
|positive regulation of viral process|
|response to retinoic acid|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|liver development|
|late endosome|
|hepaticobiliary system development|
|vacuolar transport|
|modification of morphology or physiology of other organism|
|regeneration|
|trans-Golgi network|
|signaling receptor activity|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|receptor-mediated endocytosis|
|early endosome|
|endosome|
|lysosomal membrane|
|response to acid chemical|
|enzyme binding|
|gland development|
|focal adhesion|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|spermatogenesis|
|endocytosis|
|male gamete generation|
|myeloid leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|import into cell|
|gamete generation|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|membrane organization|
|leukocyte activation|
|Golgi apparatus|
|multi-organism reproductive process|
|secretion by cell|
|export from cell|
|identical protein binding|
|cell activation|
|immune effector process|
|secretion|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell death|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6645
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IGF2R Expression in NALM6 Cells: 8.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>