IHH [The Human Chemical-Genetic Interaction Map Project]

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======= IHH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IHH
  * **<color #00a2e8>Official Name</color>**: Indian hedgehog signaling molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3549|3549]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14623|Q14623]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IHH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IHH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600726|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). {ECO:0000250, ECO:0000269|PubMed:21537345}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hint|
|HH signal|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vitelline membrane formation|
|photoreceptor cell fate commitment|
|negative regulation of eye pigmentation|
|eye photoreceptor cell fate commitment|
|negative regulation of developmental pigmentation|
|camera-type eye photoreceptor cell fate commitment|
|protein splicing|
|intein-mediated protein splicing|
|regulation of eye pigmentation|
|egg coat formation|
|negative regulation of immature T cell proliferation in thymus|
|retinal pigment epithelium development|
|negative regulation of immature T cell proliferation|
|regulation of immature T cell proliferation in thymus|
|negative regulation of T cell differentiation in thymus|
|regulation of immature T cell proliferation|
|patched binding|
|chondrocyte proliferation|
|positive regulation of T cell differentiation in thymus|
|embryonic skeletal joint development|
|epithelial cell-cell adhesion|
|regulation of developmental pigmentation|
|smooth muscle tissue development|
|embryonic digestive tract morphogenesis|
|camera-type eye photoreceptor cell differentiation|
|extracellular matrix assembly|
|negative regulation of alpha-beta T cell differentiation|
|bone resorption|
|regulation of T cell differentiation in thymus|
|positive regulation of mesenchymal cell proliferation|
|positive regulation of collagen biosynthetic process|
|embryonic camera-type eye morphogenesis|
|positive regulation of collagen metabolic process|
|branching involved in blood vessel morphogenesis|
|liver regeneration|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|positive regulation of smoothened signaling pathway|
|regulation of mesenchymal cell proliferation|
|epithelial cell morphogenesis|
|embryonic eye morphogenesis|
|embryonic digestive tract development|
|regulation of collagen biosynthetic process|
|embryonic camera-type eye development|
|head morphogenesis|
|negative regulation of alpha-beta T cell activation|
|regulation of collagen metabolic process|
|negative regulation of T cell differentiation|
|eye photoreceptor cell differentiation|
|body morphogenesis|
|cartilage development involved in endochondral bone morphogenesis|
|positive regulation of alpha-beta T cell differentiation|
|bone remodeling|
|digestive tract morphogenesis|
|retina morphogenesis in camera-type eye|
|negative regulation of lymphocyte differentiation|
|neural retina development|
|photoreceptor cell differentiation|
|negative regulation of T cell proliferation|
|positive regulation of alpha-beta T cell activation|
|heart looping|
|embryonic digit morphogenesis|
|regulation of alpha-beta T cell differentiation|
|embryonic pattern specification|
|maternal process involved in female pregnancy|
|neuron fate commitment|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|endochondral bone morphogenesis|
|pancreas development|
|smoothened signaling pathway|
|animal organ regeneration|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|embryonic heart tube development|
|regulation of smoothened signaling pathway|
|oogenesis|
|negative regulation of leukocyte proliferation|
|peptidase activity|
|chondrocyte differentiation|
|somite development|
|multicellular organism growth|
|positive regulation of T cell differentiation|
|cell fate specification|
|regulation of alpha-beta T cell activation|
|proteoglycan metabolic process|
|positive regulation of lymphocyte differentiation|
|negative regulation of leukocyte differentiation|
|tissue remodeling|
|cellular component assembly involved in morphogenesis|
|negative regulation of T cell activation|
|camera-type eye morphogenesis|
|bone morphogenesis|
|determination of left/right symmetry|
|negative regulation of leukocyte cell-cell adhesion|
|determination of bilateral symmetry|
|specification of symmetry|
|liver development|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|embryonic skeletal system development|
|osteoblast differentiation|
|hepaticobiliary system development|
|female gamete generation|
|digestive tract development|
|branching morphogenesis of an epithelial tube|
|response to estradiol|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|retina development in camera-type eye|
|digestive system development|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|eye morphogenesis|
|appendage morphogenesis|
|limb morphogenesis|
|regulation of T cell proliferation|
|regeneration|
|protein processing|
|cell maturation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|regulation of lymphocyte differentiation|
|cartilage development|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|appendage development|
|limb development|
|female pregnancy|
|positive regulation of hemopoiesis|
|positive regulation of epithelial cell proliferation|
|tissue homeostasis|
|epithelial cell development|
|negative regulation of cell activation|
|bone development|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|multi-multicellular organism process|
|response to mechanical stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|connective tissue development|
|protein maturation|
|extracellular matrix|
|skeletal system morphogenesis|
|developmental maturation|
|cell fate commitment|
|heart morphogenesis|
|positive regulation of cell-cell adhesion|
|sensory organ morphogenesis|
|germ cell development|
|ossification|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|embryonic organ morphogenesis|
|regulation of leukocyte cell-cell adhesion|
|muscle tissue development|
|epithelial tube morphogenesis|
|camera-type eye development|
|angiogenesis|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|regulation of epithelial cell proliferation|
|extracellular matrix organization|
|anatomical structure homeostasis|
|cellular process involved in reproduction in multicellular organism|
|eye development|
|positive regulation of lymphocyte activation|
|visual system development|
|sensory system development|
|in utero embryonic development|
|glycoprotein metabolic process|
|extracellular structure organization|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|blood vessel morphogenesis|
|gland development|
|positive regulation of cell activation|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|blood vessel development|
|skeletal system development|
|cell-cell adhesion|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|heart development|
|sensory organ development|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|regulation of leukocyte activation|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|epithelial cell differentiation|
|gamete generation|
|negative regulation of cell differentiation|
|calcium ion binding|
|cell morphogenesis|
|head development|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|negative regulation of cell death|
|multi-organism reproductive process|
|neuron differentiation|
|carbohydrate derivative metabolic process|
|epithelium development|
|cell-cell signaling|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7160
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IHH Expression in NALM6 Cells: -3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>