IKZF2 [The Human Chemical-Genetic Interaction Map Project]

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======= IKZF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IKZF2
  * **<color #00a2e8>Official Name</color>**: IKAROS family zinc finger 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22807|22807]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKS7|Q9UKS7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IKZF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IKZF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606234|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription regulatory region DNA binding|
|DNA-binding transcription factor activity|
|molecular function|
|protein homodimerization activity|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-3.02|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.94|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.54|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.3|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.24|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.14|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.94|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.9|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.89|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.83|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.85|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.9|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.92|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.94|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.94|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.01|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.02|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.11|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.17|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.18|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.29|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.59|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.96|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|3.41|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.46|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|3.93|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|4.16|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|6.2|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|7.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ikzf1|IKZF1]]|0.59|
|[[:human genes:u:ube2e1|UBE2E1]]|0.551|
|[[:human genes:p:pou2af1|POU2AF1]]|0.49|
|[[:human genes:g:glyr1|GLYR1]]|0.484|
|[[:human genes:c:creb1|CREB1]]|0.463|
|[[:human genes:p:pcgf1|PCGF1]]|0.456|
|[[:human genes:n:nf1|NF1]]|0.442|
|[[:human genes:z:zbtb7a|ZBTB7A]]|0.44|
|[[:human genes:b:bcor|BCOR]]|0.439|
|[[:human genes:c:cxorf38|CXorf38]]|0.437|
|[[:human genes:t:tnfrsf10b|TNFRSF10B]]|0.432|
|[[:human genes:z:znf217|ZNF217]]|0.424|
|[[:human genes:r:ring1|RING1]]|0.423|
|[[:human genes:p:ptma|PTMA]]|0.419|
|[[:human genes:e:eif4a1|EIF4A1]]|0.409|
|[[:human genes:c:cebpg|CEBPG]]|0.404|
|[[:human genes:y:ylpm1|YLPM1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10754
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IKZF2 Expression in NALM6 Cells: 7.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>