IL12B [The Human Chemical-Genetic Interaction Map Project]

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======= IL12B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL12B
  * **<color #00a2e8>Official Name</color>**: interleukin 12B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3593|3593]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29460|P29460]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL12B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL12B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/161561|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. {ECO:0000269|PubMed:11114383}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL12p40 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-12 alpha subunit binding|
|late endosome lumen|
|interferon-gamma biosynthetic process|
|interleukin-23 complex|
|interleukin-12 complex|
|interleukin-23 receptor binding|
|T-helper 1 cell cytokine production|
|positive regulation of NK T cell proliferation|
|positive regulation of T-helper 17 cell lineage commitment|
|regulation of NK T cell proliferation|
|regulation of T-helper 17 cell lineage commitment|
|positive regulation of memory T cell differentiation|
|interleukin-12 receptor binding|
|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|positive regulation of activation of Janus kinase activity|
|CD4-positive, alpha-beta T cell cytokine production|
|positive regulation of natural killer cell mediated immune response to tumor cell|
|positive regulation of natural killer cell proliferation|
|positive regulation of T-helper 17 cell differentiation|
|positive regulation of NK T cell activation|
|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|positive regulation of cell fate commitment|
|regulation of natural killer cell mediated immune response to tumor cell|
|regulation of natural killer cell proliferation|
|regulation of activation of Janus kinase activity|
|regulation of memory T cell differentiation|
|interleukin-23-mediated signaling pathway|
|T cell cytokine production|
|positive regulation of T-helper 17 type immune response|
|regulation of NK T cell activation|
|positive regulation of immune response to tumor cell|
|positive regulation of response to tumor cell|
|negative regulation of inflammatory response to antigenic stimulus|
|positive regulation of granulocyte macrophage colony-stimulating factor production|
|positive regulation of interferon-gamma biosynthetic process|
|cytokine biosynthetic process|
|negative regulation of interleukin-17 production|
|regulation of response to tumor cell|
|regulation of immune response to tumor cell|
|regulation of granulocyte macrophage colony-stimulating factor production|
|cytokine metabolic process|
|positive regulation of smooth muscle cell apoptotic process|
|regulation of T-helper 17 cell differentiation|
|positive regulation of interleukin-17 production|
|regulation of interferon-gamma biosynthetic process|
|response to UV-B|
|negative regulation of interleukin-10 production|
|interferon-gamma production|
|T-helper 1 type immune response|
|positive regulation of alpha-beta T cell proliferation|
|regulation of T-helper 17 type immune response|
|positive regulation of natural killer cell activation|
|positive regulation of T-helper 1 type immune response|
|positive regulation of T-helper cell differentiation|
|positive regulation of activated T cell proliferation|
|cytokine production involved in immune response|
|defense response to protozoan|
|natural killer cell activation involved in immune response|
|regulation of inflammatory response to antigenic stimulus|
|regulation of smooth muscle cell apoptotic process|
|response to protozoan|
|positive regulation of T cell mediated cytotoxicity|
|positive regulation of defense response to virus by host|
|positive regulation of osteoclast differentiation|
|T-helper cell differentiation|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|regulation of T-helper 1 type immune response|
|regulation of cell fate commitment|
|alpha-beta T cell activation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|positive regulation of muscle cell apoptotic process|
|regulation of interleukin-17 production|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of natural killer cell mediated cytotoxicity|
|regulation of alpha-beta T cell proliferation|
|positive regulation of tissue remodeling|
|regulation of natural killer cell activation|
|T cell differentiation involved in immune response|
|positive regulation of natural killer cell mediated immunity|
|regulation of T cell mediated cytotoxicity|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|regulation of T-helper cell differentiation|
|CD4-positive, alpha-beta T cell differentiation|
|positive regulation of interleukin-12 production|
|regulation of activated T cell proliferation|
|positive regulation of interleukin-10 production|
|regulation of defense response to virus by host|
|CD4-positive, alpha-beta T cell activation|
|cytokine binding|
|T cell mediated immunity|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|negative regulation of smooth muscle cell proliferation|
|interleukin-12-mediated signaling pathway|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|cytokine receptor activity|
|positive regulation of T cell mediated immunity|
|cellular response to interleukin-12|
|response to interleukin-12|
|alpha-beta T cell differentiation|
|regulation of interleukin-10 production|
|regulation of interleukin-12 production|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of leukocyte mediated cytotoxicity|
|natural killer cell activation|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|T cell activation involved in immune response|
|positive regulation of interferon-gamma production|
|regulation of osteoclast differentiation|
|positive regulation of cell killing|
|positive regulation of cytokine biosynthetic process|
|regulation of muscle cell apoptotic process|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of T cell mediated immunity|
|regulation of tissue remodeling|
|regulation of defense response to virus|
|sensory perception of pain|
|regulation of leukocyte mediated cytotoxicity|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of T cell differentiation|
|defense response to Gram-negative bacterium|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of tumor necrosis factor production|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of myeloid cell differentiation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|regulation of cytokine biosynthetic process|
|regulation of NIK/NF-kappaB signaling|
|lymphocyte activation involved in immune response|
|regulation of myeloid leukocyte differentiation|
|positive regulation of lymphocyte proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|regulation of smooth muscle cell proliferation|
|regulation of receptor signaling pathway via STAT|
|T cell differentiation|
|negative regulation of inflammatory response|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of inflammatory response|
|response to UV|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|cell cycle arrest|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of tumor necrosis factor production|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|cellular response to interferon-gamma|
|growth factor activity|
|regulation of lymphocyte differentiation|
|cytokine activity|
|production of molecular mediator of immune response|
|response to interferon-gamma|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|defense response to virus|
|cellular response to molecule of bacterial origin|
|positive regulation of T cell activation|
|receptor complex|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|T cell activation|
|lymphocyte differentiation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to virus|
|regulation of leukocyte cell-cell adhesion|
|endoplasmic reticulum lumen|
|response to light stimulus|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|defense response to bacterium|
|leukocyte differentiation|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|response to radiation|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|protein heterodimerization activity|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|cell population proliferation|
|hemopoiesis|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|sexual reproduction|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|sensory perception|
|regulation of transferase activity|
|multi-organism reproductive process|
|cell cycle process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|cell cycle|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.02|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.74|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9000
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL12B Expression in NALM6 Cells: 0.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>