IL13RA2 [The Human Chemical-Genetic Interaction Map Project]

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======= IL13RA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL13RA2
  * **<color #00a2e8>Official Name</color>**: interleukin 13 receptor subunit alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3598|3598]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14627|Q14627]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL13RA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL13RA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). {ECO:0000269|PubMed:20223216}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL6Ra-bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mast cell degranulation|
|negative regulation of mast cell activation involved in immune response|
|negative regulation of myeloid leukocyte mediated immunity|
|negative regulation of immunoglobulin production|
|negative regulation of leukocyte degranulation|
|negative regulation of mast cell activation|
|negative regulation of regulated secretory pathway|
|negative regulation of exocytosis|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|negative regulation of production of molecular mediator of immune response|
|cytokine binding|
|regulation of mast cell activation|
|cytokine receptor activity|
|regulation of leukocyte degranulation|
|negative regulation of leukocyte mediated immunity|
|regulation of myeloid leukocyte mediated immunity|
|negative regulation of intracellular transport|
|regulation of immunoglobulin production|
|negative regulation of immune effector process|
|regulation of production of molecular mediator of immune response|
|negative regulation of immune response|
|regulation of regulated secretory pathway|
|negative regulation of leukocyte activation|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|receptor complex|
|regulation of leukocyte mediated immunity|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|positive regulation of immune effector process|
|regulation of exocytosis|
|negative regulation of secretion|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of intracellular transport|
|external side of plasma membrane|
|negative regulation of immune system process|
|regulation of immune effector process|
|negative regulation of transport|
|regulation of vesicle-mediated transport|
|regulation of leukocyte activation|
|adaptive immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|regulation of secretion|
|regulation of cellular localization|
|cellular response to cytokine stimulus|
|immune effector process|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18885
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL13RA2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>