IL18R1 [The Human Chemical-Genetic Interaction Map Project]

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======= IL18R1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL18R1
  * **<color #00a2e8>Official Name</color>**: interleukin 18 receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8809|8809]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13478|Q13478]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL18R1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL18R1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604494|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable) (PubMed:8626725). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). {ECO:0000250|UniProtKB:Q61098, ECO:0000269|PubMed:8626725, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-18 binding|
|interleukin-18 receptor activity|
|interleukin-18 receptor complex|
|positive regulation of T-helper 1 cell cytokine production|
|regulation of T-helper 1 cell cytokine production|
|cellular response to interleukin-18|
|interleukin-18-mediated signaling pathway|
|interleukin-1 receptor activity|
|T-helper 1 cell differentiation|
|response to interleukin-18|
|T-helper 1 type immune response|
|positive regulation of T cell cytokine production|
|positive regulation of T-helper 1 type immune response|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|T-helper cell differentiation|
|regulation of T-helper 1 type immune response|
|alpha-beta T cell activation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|regulation of T cell cytokine production|
|T cell differentiation involved in immune response|
|CD4-positive, alpha-beta T cell differentiation|
|CD4-positive, alpha-beta T cell activation|
|negative regulation of cold-induced thermogenesis|
|positive regulation of T cell mediated immunity|
|alpha-beta T cell differentiation|
|positive regulation of cytokine production involved in immune response|
|natural killer cell activation|
|alpha-beta T cell activation|
|T cell activation involved in immune response|
|positive regulation of interferon-gamma production|
|regulation of T cell mediated immunity|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of cytokine production involved in immune response|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|regulation of NIK/NF-kappaB signaling|
|lymphocyte activation involved in immune response|
|positive regulation of leukocyte mediated immunity|
|T cell differentiation|
|regulation of production of molecular mediator of immune response|
|regulation of cold-induced thermogenesis|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of adaptive immune response|
|signaling receptor activity|
|regulation of leukocyte mediated immunity|
|positive regulation of immune effector process|
|T cell activation|
|lymphocyte differentiation|
|positive regulation of DNA-binding transcription factor activity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte differentiation|
|lymphocyte activation|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cytokine production|
|regulation of immune effector process|
|inflammatory response|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|positive regulation of immune response|
|leukocyte activation|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|cell activation|
|immune effector process|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|defense response|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-1.8|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.82|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.86|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12847
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL18R1 Expression in NALM6 Cells: -1.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>