IL1R1 [The Human Chemical-Genetic Interaction Map Project]

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======= IL1R1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL1R1
  * **<color #00a2e8>Official Name</color>**: interleukin 1 receptor type 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3554|3554]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14778|P14778]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL1R1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL1R1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147810|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. {ECO:0000269|PubMed:10671496}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of interleukin-1-mediated signaling pathway|
|interleukin-1, type I, activating receptor activity|
|regulation of T-helper 1 cell cytokine production|
|positive regulation of T-helper 1 cell cytokine production|
|positive regulation of neutrophil extravasation|
|regulation of interleukin-1-mediated signaling pathway|
|interleukin-1 receptor activity|
|interleukin-1 binding|
|regulation of neutrophil extravasation|
|platelet-derived growth factor receptor binding|
|positive regulation of cellular extravasation|
|positive regulation of T cell cytokine production|
|positive regulation of T-helper 1 type immune response|
|regulation of T-helper 1 type immune response|
|regulation of cellular extravasation|
|positive regulation of neutrophil migration|
|regulation of T cell cytokine production|
|regulation of neutrophil migration|
|positive regulation of T cell mediated immunity|
|positive regulation of cytokine-mediated signaling pathway|
|positive regulation of cytokine production involved in immune response|
|positive regulation of response to cytokine stimulus|
|positive regulation of interferon-gamma production|
|regulation of T cell mediated immunity|
|regulation of cytokine production involved in immune response|
|interleukin-1-mediated signaling pathway|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|protease binding|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of leukocyte migration|
|positive regulation of leukocyte mediated immunity|
|transmembrane signaling receptor activity|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|regulation of cytokine-mediated signaling pathway|
|cellular response to interleukin-1|
|regulation of response to cytokine stimulus|
|regulation of leukocyte migration|
|response to interleukin-1|
|regulation of leukocyte mediated immunity|
|positive regulation of immune effector process|
|regulation of inflammatory response|
|external side of plasma membrane|
|positive regulation of cytokine production|
|regulation of immune effector process|
|inflammatory response|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of defense response|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13321
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL1R1 Expression in NALM6 Cells: 1.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>