IL27RA [The Human Chemical-Genetic Interaction Map Project]

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======= IL27RA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL27RA
  * **<color #00a2e8>Official Name</color>**: interleukin 27 receptor subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9466|9466]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UWB1|Q6UWB1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL27RA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL27RA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms. {ECO:0000269|PubMed:14764690}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of T cell extravasation|
|interleukin-27 receptor activity|
|negative regulation of interleukin-17 secretion|
|regulation of interleukin-17 secretion|
|regulation of T cell extravasation|
|negative regulation of T cell migration|
|negative regulation of tumor necrosis factor secretion|
|negative regulation of cellular extravasation|
|negative regulation of T-helper 17 type immune response|
|interleukin-35-mediated signaling pathway|
|negative regulation of interleukin-6 secretion|
|interleukin-27-mediated signaling pathway|
|regulation of isotype switching to IgG isotypes|
|negative regulation of type 2 immune response|
|negative regulation of lymphocyte migration|
|negative regulation of interleukin-17 production|
|positive regulation of T-helper 1 type immune response|
|regulation of T-helper 17 type immune response|
|regulation of T-helper 1 type immune response|
|regulation of tumor necrosis factor secretion|
|regulation of cellular extravasation|
|regulation of interleukin-17 production|
|regulation of type 2 immune response|
|regulation of isotype switching|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|cytokine binding|
|negative regulation of interleukin-6 production|
|regulation of T cell migration|
|negative regulation of leukocyte migration|
|negative regulation of adaptive immune response|
|cytokine receptor activity|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|regulation of lymphocyte migration|
|regulation of immunoglobulin production|
|positive regulation of interferon-gamma production|
|negative regulation of cytokine secretion|
|defense response to Gram-positive bacterium|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of DNA recombination|
|positive regulation of adaptive immune response|
|negative regulation of protein secretion|
|transmembrane signaling receptor activity|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of tumor necrosis factor production|
|regulation of lymphocyte mediated immunity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of adaptive immune response|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of leukocyte migration|
|negative regulation of secretion by cell|
|receptor complex|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|negative regulation of secretion|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of cytokine production|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|defense response to bacterium|
|regulation of DNA metabolic process|
|external side of plasma membrane|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of protein secretion|
|regulation of immune effector process|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of cell motility|
|defense response to other organism|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16075
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL27RA Expression in NALM6 Cells: 3.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>