IL2RA [The Human Chemical-Genetic Interaction Map Project]

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======= IL2RA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL2RA
  * **<color #00a2e8>Official Name</color>**: interleukin 2 receptor subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3559|3559]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01589|P01589]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL2RA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL2RA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. {ECO:0000269|PubMed:23416241, ECO:0000269|PubMed:24116927}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-2 receptor complex|
|interleukin-2 receptor activity|
|interleukin-2 binding|
|regulation of T cell homeostatic proliferation|
|activation-induced cell death of T cells|
|regulation of T cell tolerance induction|
|interleukin-2-mediated signaling pathway|
|cellular response to interleukin-2|
|response to interleukin-2|
|T cell apoptotic process|
|regulation of tolerance induction|
|lymphocyte apoptotic process|
|positive regulation of activated T cell proliferation|
|negative regulation of defense response to virus|
|leukocyte apoptotic process|
|inflammatory response to antigenic stimulus|
|regulation of regulatory T cell differentiation|
|T cell homeostasis|
|regulation of activated T cell proliferation|
|lymphocyte homeostasis|
|negative regulation of T cell proliferation|
|leukocyte homeostasis|
|regulation of defense response to virus|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|positive regulation of T cell differentiation|
|negative regulation of response to biotic stimulus|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|negative regulation of T cell activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|Notch signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|negative regulation of inflammatory response|
|regulation of T cell differentiation|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of T cell proliferation|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|positive regulation of hemopoiesis|
|negative regulation of cell activation|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|negative regulation of multi-organism process|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of inflammatory response|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of immune effector process|
|inflammatory response|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of cell population proliferation|
|apoptotic process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|cellular response to cytokine stimulus|
|programmed cell death|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|phosphorylation|
|defense response|
|positive regulation of developmental process|
|regulation of response to stress|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4485
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL2RA Expression in NALM6 Cells: 1.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>