IL2RG [The Human Chemical-Genetic Interaction Map Project]

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======= IL2RG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL2RG
  * **<color #00a2e8>Official Name</color>**: interleukin 2 receptor subunit gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3561|3561]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31785|P31785]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL2RG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL2RG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/308380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Common subunit for the receptors for a variety of interleukins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EpoR lig-bind|
|IL6Ra-bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-4 receptor activity|
|interleukin-7 receptor activity|
|interleukin-2 binding|
|interleukin-2 receptor activity|
|interleukin-15 receptor activity|
|interleukin-4-mediated signaling pathway|
|response to interleukin-21|
|interleukin-21-mediated signaling pathway|
|cellular response to interleukin-21|
|cellular response to interleukin-9|
|interleukin-9-mediated signaling pathway|
|response to interleukin-9|
|interleukin-2-mediated signaling pathway|
|cellular response to interleukin-2|
|cellular response to interleukin-15|
|response to interleukin-2|
|interleukin-15-mediated signaling pathway|
|response to interleukin-15|
|interleukin-7-mediated signaling pathway|
|cellular response to interleukin-7|
|response to interleukin-7|
|cellular response to interleukin-4|
|response to interleukin-4|
|cytokine binding|
|cytokine receptor activity|
|positive regulation of phagocytosis|
|regulation of phagocytosis|
|receptor complex|
|endosome|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|regulation of vesicle-mediated transport|
|cell surface|
|cytokine-mediated signaling pathway|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|protein phosphorylation|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|response to cytokine|
|phosphorylation|
|integral component of plasma membrane|
|intracellular signal transduction|
|regulation of transport|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.78|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18497
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL2RG Expression in NALM6 Cells: 5.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>