IL6R [The Human Chemical-Genetic Interaction Map Project]

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======= IL6R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL6R
  * **<color #00a2e8>Official Name</color>**: interleukin 6 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3570|3570]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08887|P08887]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL6R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL6R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL6Ra-bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ciliary neurotrophic factor binding|
|interleukin-6 receptor activity|
|interleukin-12 alpha subunit binding|
|interleukin-6 binding|
|hepatic immune response|
|interleukin-23 receptor binding|
|interleukin-6 receptor complex|
|interleukin-12 complex|
|interleukin-23 complex|
|ciliary neurotrophic factor receptor complex|
|ciliary neurotrophic factor receptor activity|
|interleukin-12 receptor binding|
|positive regulation of glomerular mesangial cell proliferation|
|ciliary neurotrophic factor-mediated signaling pathway|
|interleukin-6 receptor binding|
|positive regulation of activation of Janus kinase activity|
|positive regulation of NK T cell activation|
|positive regulation of cell proliferation involved in kidney development|
|regulation of activation of Janus kinase activity|
|regulation of NK T cell activation|
|regulation of glomerular mesangial cell proliferation|
|positive regulation of glomerulus development|
|regulation of cell proliferation involved in kidney development|
|regulation of glomerulus development|
|interleukin-6-mediated signaling pathway|
|positive regulation of T-helper 1 type immune response|
|positive regulation of natural killer cell activation|
|positive regulation of activated T cell proliferation|
|regulation of T-helper 1 type immune response|
|cellular response to interleukin-6|
|organ or tissue specific immune response|
|regulation of natural killer cell activation|
|response to interleukin-6|
|regulation of activated T cell proliferation|
|endocrine pancreas development|
|acute-phase response|
|cytokine binding|
|positive regulation of kidney development|
|monocyte chemotaxis|
|cytokine receptor activity|
|mononuclear cell migration|
|regulation of kidney development|
|positive regulation of chemokine production|
|positive regulation of osteoblast differentiation|
|positive regulation of alpha-beta T cell activation|
|positive regulation of interferon-gamma production|
|positive regulation of tyrosine phosphorylation of STAT protein|
|acute inflammatory response|
|pancreas development|
|regulation of chemokine production|
|regulation of tyrosine phosphorylation of STAT protein|
|defense response to Gram-negative bacterium|
|positive regulation of ossification|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of leukocyte chemotaxis|
|positive regulation of receptor signaling pathway via STAT|
|regulation of alpha-beta T cell activation|
|positive regulation of T cell proliferation|
|positive regulation of interleukin-6 production|
|extrinsic apoptotic signaling pathway|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|regulation of osteoblast differentiation|
|regulation of leukocyte chemotaxis|
|endocrine system development|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|regulation of smooth muscle cell proliferation|
|regulation of receptor signaling pathway via STAT|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|regulation of interleukin-6 production|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte chemotaxis|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|growth factor activity|
|positive regulation of vasculature development|
|regulation of ossification|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of leukocyte migration|
|basolateral plasma membrane|
|positive regulation of T cell activation|
|receptor complex|
|regulation of lymphocyte proliferation|
|cell chemotaxis|
|regulation of mononuclear cell proliferation|
|regulation of chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|apoptotic signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|apical plasma membrane|
|regulation of vasculature development|
|defense response to bacterium|
|enzyme binding|
|positive regulation of lymphocyte activation|
|leukocyte migration|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|inflammatory response|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein kinase activity|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|programmed cell death|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4437
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL6R Expression in NALM6 Cells: 2.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>