IL6ST [The Human Chemical-Genetic Interaction Map Project]

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======= IL6ST =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL6ST
  * **<color #00a2e8>Official Name</color>**: interleukin 6 signal transducer
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3572|3572]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40189|P40189]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL6ST&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL6ST|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600694|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL6Ra-bind|
|fn3|
|EpoR lig-bind|
|Lep receptor Ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-6 binding|
|interleukin-11-mediated signaling pathway|
|oncostatin-M receptor complex|
|interleukin-27 receptor activity|
|interleukin-6 receptor activity|
|leukemia inhibitory factor receptor activity|
|interleukin-11 binding|
|interleukin-11 receptor activity|
|interleukin-6 receptor complex|
|oncostatin-M receptor activity|
|oncostatin-M-mediated signaling pathway|
|ciliary neurotrophic factor receptor complex|
|leukemia inhibitory factor signaling pathway|
|ciliary neurotrophic factor receptor activity|
|ciliary neurotrophic factor receptor binding|
|ciliary neurotrophic factor-mediated signaling pathway|
|interleukin-6 receptor binding|
|interleukin-35-mediated signaling pathway|
|interleukin-27-mediated signaling pathway|
|positive regulation of astrocyte differentiation|
|interleukin-6-mediated signaling pathway|
|regulation of astrocyte differentiation|
|positive regulation of vascular endothelial growth factor production|
|positive regulation of acute inflammatory response|
|positive regulation of cardiac muscle hypertrophy|
|positive regulation of muscle hypertrophy|
|growth factor binding|
|cellular response to interleukin-6|
|regulation of vascular endothelial growth factor production|
|response to interleukin-6|
|cytokine binding|
|positive regulation of glial cell differentiation|
|regulation of acute inflammatory response|
|cytokine receptor activity|
|glycogen metabolic process|
|glucan metabolic process|
|cellular glucan metabolic process|
|regulation of cardiac muscle hypertrophy|
|positive regulation of osteoblast differentiation|
|regulation of muscle hypertrophy|
|energy reserve metabolic process|
|positive regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of gliogenesis|
|regulation of glial cell differentiation|
|cellular polysaccharide metabolic process|
|regulation of tyrosine phosphorylation of STAT protein|
|polysaccharide metabolic process|
|positive regulation of ossification|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of muscle adaptation|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of T cell proliferation|
|regulation of Notch signaling pathway|
|positive regulation of adaptive immune response|
|regulation of osteoblast differentiation|
|regulation of gliogenesis|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|regulation of receptor signaling pathway via STAT|
|positive regulation of leukocyte proliferation|
|positive regulation of inflammatory response|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|cellular carbohydrate metabolic process|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of ossification|
|positive regulation of T cell activation|
|receptor complex|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|regulation of muscle system process|
|energy derivation by oxidation of organic compounds|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of inflammatory response|
|positive regulation of lymphocyte activation|
|neuronal cell body|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|dendrite|
|generation of precursor metabolites and energy|
|positive regulation of cytokine production|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|carbohydrate metabolic process|
|regulation of lymphocyte activation|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of system process|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|viral process|
|enzyme linked receptor protein signaling pathway|
|regulation of defense response|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|positive regulation of immune response|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|identical protein binding|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.72|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.96|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5477
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL6ST Expression in NALM6 Cells: 3.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>