INHBB [The Human Chemical-Genetic Interaction Map Project]

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======= INHBB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INHBB
  * **<color #00a2e8>Official Name</color>**: inhibin subunit beta B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3625|3625]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09529|P09529]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INHBB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INHBB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGF beta|
|TGFb propeptide|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of hepatocyte growth factor biosynthetic process|
|regulation of hepatocyte growth factor production|
|negative regulation of hepatocyte growth factor production|
|regulation of hepatocyte growth factor biosynthetic process|
|host cell surface receptor binding|
|positive regulation of ovulation|
|negative regulation of follicle-stimulating hormone secretion|
|regulation of ovulation|
|positive regulation of follicle-stimulating hormone secretion|
|regulation of follicle-stimulating hormone secretion|
|positive regulation of gonadotropin secretion|
|negative regulation of gonadotropin secretion|
|regulation of gonadotropin secretion|
|adhesion of symbiont to host cell|
|adhesion of symbiont to host|
|cellular response to leptin stimulus|
|response to leptin|
|activin receptor signaling pathway|
|negative regulation of cytokine biosynthetic process|
|cell periphery|
|oocyte development|
|negative regulation of insulin secretion|
|transforming growth factor beta receptor binding|
|oocyte differentiation|
|regulation of endocrine process|
|negative regulation of peptide hormone secretion|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|ovarian follicle development|
|SMAD protein signal transduction|
|regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of hormone secretion|
|oogenesis|
|positive regulation of reproductive process|
|female gonad development|
|development of primary female sexual characteristics|
|hormone activity|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cytokine biosynthetic process|
|fat cell differentiation|
|female sex differentiation|
|positive regulation of hormone secretion|
|female gamete generation|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|cellular response to starvation|
|regulation of reproductive process|
|cellular response to insulin stimulus|
|growth factor activity|
|cytokine activity|
|positive regulation of apoptotic signaling pathway|
|regulation of insulin secretion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|response to starvation|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|gonad development|
|development of primary sexual characteristics|
|response to insulin|
|negative regulation of secretion|
|cellular response to nutrient levels|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|germ cell development|
|cellular response to extracellular stimulus|
|sex differentiation|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|negative regulation of cytokine production|
|cellular response to peptide|
|cellular response to external stimulus|
|cellular process involved in reproduction in multicellular organism|
|response to peptide hormone|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|reproductive structure development|
|reproductive system development|
|positive regulation of secretion|
|regulation of protein secretion|
|response to peptide|
|negative regulation of transport|
|regulation of peptide secretion|
|response to nutrient levels|
|positive regulation of multi-organism process|
|response to extracellular stimulus|
|regulation of hormone levels|
|response to wounding|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|gamete generation|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of multi-organism process|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|protein homodimerization activity|
|response to hormone|
|biological adhesion|
|positive regulation of transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11350
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INHBB Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>