INPP5F [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= INPP5F =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INPP5F
  * **<color #00a2e8>Official Name</color>**: inositol polyphosphate-5-phosphatase F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22876|22876]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2H2|Q9Y2H2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INPP5F&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INPP5F|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609389|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Syja N|
|hSac2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol catabolic process|
|phosphatidylinositol phosphate 4-phosphatase activity|
|phosphatidylinositol phosphate 5-phosphatase activity|
|inositol monophosphate 1-phosphatase activity|
|phosphatidylinositol-4-phosphate phosphatase activity|
|inositol monophosphate 4-phosphatase activity|
|inositol monophosphate 3-phosphatase activity|
|regulation of endocytic recycling|
|negative regulation of tyrosine phosphorylation of STAT protein|
|negative regulation of axon regeneration|
|muscle hypertrophy in response to stress|
|cardiac muscle adaptation|
|cardiac muscle hypertrophy in response to stress|
|positive regulation of receptor recycling|
|negative regulation of neuron projection regeneration|
|negative regulation of receptor signaling pathway via JAK-STAT|
|glycerophospholipid catabolic process|
|negative regulation of receptor signaling pathway via STAT|
|phosphatidylinositol dephosphorylation|
|regulation of receptor recycling|
|regulation of axon regeneration|
|negative regulation of peptidyl-serine phosphorylation|
|clathrin-coated endocytic vesicle|
|clathrin-dependent endocytosis|
|striated muscle adaptation|
|regulation of neuron projection regeneration|
|cardiac muscle hypertrophy|
|striated muscle hypertrophy|
|muscle hypertrophy|
|muscle adaptation|
|phospholipid dephosphorylation|
|phospholipid catabolic process|
|negative regulation of peptidyl-tyrosine phosphorylation|
|glycerolipid catabolic process|
|clathrin-coated pit|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|adult locomotory behavior|
|regulation of tyrosine phosphorylation of STAT protein|
|negative regulation of response to wounding|
|phosphatidylinositol biosynthetic process|
|recycling endosome|
|organophosphate catabolic process|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|regulation of peptidyl-serine phosphorylation|
|adult behavior|
|early endosome membrane|
|negative regulation of neuron projection development|
|regulation of response to wounding|
|phosphatidylinositol metabolic process|
|negative regulation of cell projection organization|
|locomotory behavior|
|cellular lipid catabolic process|
|lipid modification|
|glycerophospholipid biosynthetic process|
|regulation of protein kinase B signaling|
|glycerolipid biosynthetic process|
|negative regulation of neuron differentiation|
|receptor-mediated endocytosis|
|phospholipid biosynthetic process|
|regulation of peptidyl-tyrosine phosphorylation|
|early endosome|
|negative regulation of neurogenesis|
|axon|
|lipid catabolic process|
|muscle system process|
|glycerophospholipid metabolic process|
|dephosphorylation|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of intracellular transport|
|negative regulation of response to external stimulus|
|neuronal cell body|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|negative regulation of protein phosphorylation|
|dendrite|
|negative regulation of phosphorylation|
|regulation of neuron projection development|
|organophosphate biosynthetic process|
|regulation of vesicle-mediated transport|
|endocytosis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|lipid biosynthetic process|
|negative regulation of protein modification process|
|regulation of neuron differentiation|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of neurogenesis|
|protein homodimerization activity|
|organophosphate metabolic process|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|neurogenesis|
|intracellular signal transduction|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.97|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.91|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.88|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.75|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.71|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.81|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|2.12|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15414
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INPP5F Expression in NALM6 Cells: 3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>