INSIG2 [The Human Chemical-Genetic Interaction Map Project]

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======= INSIG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INSIG2
  * **<color #00a2e8>Official Name</color>**: insulin induced gene 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51141|51141]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5U4|Q9Y5U4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INSIG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INSIG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:16606821}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|INSIG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SREBP-SCAP-Insig complex|
|SREBP signaling pathway|
|cellular response to sterol depletion|
|cranial suture morphogenesis|
|response to sterol depletion|
|negative regulation of fatty acid biosynthetic process|
|craniofacial suture morphogenesis|
|middle ear morphogenesis|
|negative regulation of steroid biosynthetic process|
|negative regulation of steroid metabolic process|
|negative regulation of fatty acid metabolic process|
|ER-nucleus signaling pathway|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of fatty acid biosynthetic process|
|sterol biosynthetic process|
|negative regulation of lipid biosynthetic process|
|cranial skeletal system development|
|triglyceride metabolic process|
|negative regulation of lipid metabolic process|
|response to fatty acid|
|regulation of fatty acid metabolic process|
|regulation of steroid biosynthetic process|
|roof of mouth development|
|negative regulation of small molecule metabolic process|
|inner ear morphogenesis|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|alcohol biosynthetic process|
|bone morphogenesis|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|ear morphogenesis|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|regulation of cellular ketone metabolic process|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|inner ear development|
|bone development|
|ear development|
|response to insulin|
|skeletal system morphogenesis|
|sensory organ morphogenesis|
|steroid metabolic process|
|embryonic organ morphogenesis|
|alcohol metabolic process|
|transcription factor binding|
|response to acid chemical|
|glycerolipid metabolic process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|embryonic organ development|
|organic hydroxy compound metabolic process|
|response to peptide|
|skeletal system development|
|sensory organ development|
|embryonic morphogenesis|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|response to lipid|
|response to hormone|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|embryo development|
|response to organonitrogen compound|
|response to nitrogen compound|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.541|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17692
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INSIG2 Expression in NALM6 Cells: 4.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>