INSRR [The Human Chemical-Genetic Interaction Map Project]

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======= INSRR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INSRR
  * **<color #00a2e8>Official Name</color>**: insulin receptor related receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3645|3645]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14616|P14616]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INSRR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INSRR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147671|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. {ECO:0000269|PubMed:21641549}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|Recep L domain|
|Furin-like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to alkaline pH|
|response to alkaline pH|
|insulin-activated receptor activity|
|insulin receptor complex|
|insulin receptor substrate binding|
|male sex determination|
|phosphatidylinositol 3-kinase binding|
|cellular response to pH|
|sex determination|
|response to pH|
|transmembrane receptor protein tyrosine kinase activity|
|actin cytoskeleton reorganization|
|insulin receptor signaling pathway|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|cellular response to insulin stimulus|
|protein autophosphorylation|
|receptor complex|
|response to insulin|
|cellular response to peptide hormone stimulus|
|axon|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|cellular response to peptide|
|response to peptide hormone|
|response to peptide|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|actin filament-based process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|enzyme linked receptor protein signaling pathway|
|peptidyl-amino acid modification|
|response to hormone|
|protein phosphorylation|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cytoskeleton organization|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|phosphorylation|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5302
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INSRR Expression in NALM6 Cells: -2.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>