IPO11 [The Human Chemical-Genetic Interaction Map Project]

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======= IPO11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IPO11
  * **<color #00a2e8>Official Name</color>**: importin 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51194|51194]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UI26|Q9UI26]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IPO11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IPO11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610889|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11032817}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IBN N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal protein import into nucleus|
|nuclear import signal receptor activity|
|Ran GTPase binding|
|protein import into nucleus|
|import into nucleus|
|fibrillar center|
|protein import|
|protein localization to nucleus|
|nuclear envelope|
|nucleocytoplasmic transport|
|nuclear transport|
|establishment of protein localization to organelle|
|protein localization to organelle|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.92|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.6|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.46|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.44|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.34|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.24|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.08|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.93|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.9|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.89|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.88|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.82|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.81|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.72|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.8|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.8|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.85|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.59|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fam122a|FAM122A]]|0.448|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 438/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|10/28|
|bone|17/26|
|breast|23/33|
|central nervous system|36/56|
|cervix|1/4|
|colorectal|10/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|7/16|
|kidney|10/21|
|liver|9/20|
|lung|51/75|
|lymphocyte|10/16|
|ovary|16/26|
|pancreas|17/24|
|peripheral nervous system|12/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|16/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1115
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IPO11 Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>