IPO13 [The Human Chemical-Genetic Interaction Map Project]

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======= IPO13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IPO13
  * **<color #00a2e8>Official Name</color>**: importin 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9670|9670]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94829|O94829]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IPO13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IPO13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. {ECO:0000250, ECO:0000269|PubMed:11447110, ECO:0000269|PubMed:15143176}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Xpo1|
|IBN N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ran GTPase binding|
|protein import into nucleus|
|import into nucleus|
|protein import|
|protein localization to nucleus|
|nucleocytoplasmic transport|
|nuclear transport|
|establishment of protein localization to organelle|
|protein localization to organelle|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.29|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.04|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.96|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.87|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.85|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.79|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.74|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.73|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.7|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.7|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.71|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.75|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.76|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.87|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.94|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.537|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 289/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|15/28|
|bone|14/26|
|breast|15/33|
|central nervous system|17/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|7/16|
|kidney|10/21|
|liver|5/20|
|lung|35/75|
|lymphocyte|9/16|
|ovary|7/26|
|pancreas|10/24|
|peripheral nervous system|11/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1149
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IPO13 Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>