IRF4 [The Human Chemical-Genetic Interaction Map Project]

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======= IRF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRF4
  * **<color #00a2e8>Official Name</color>**: interferon regulatory factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3662|3662]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15306|Q15306]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601900|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). {ECO:0000250|UniProtKB:Q64287}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRF-3|
|IRF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of interleukin-13 biosynthetic process|
|positive regulation of interleukin-13 biosynthetic process|
|positive regulation of interleukin-4 biosynthetic process|
|regulation of interleukin-4 biosynthetic process|
|positive regulation of interleukin-10 biosynthetic process|
|regulation of interleukin-10 biosynthetic process|
|T-helper 17 cell lineage commitment|
|T-helper 17 cell differentiation|
|T-helper 17 type immune response|
|T-helper cell lineage commitment|
|CD4-positive, alpha-beta T cell lineage commitment|
|positive regulation of interleukin-2 biosynthetic process|
|alpha-beta T cell lineage commitment|
|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|
|nuclear nucleosome|
|positive regulation of interleukin-13 production|
|myeloid dendritic cell differentiation|
|regulation of interleukin-2 biosynthetic process|
|T cell lineage commitment|
|regulation of interleukin-13 production|
|myeloid dendritic cell activation|
|defense response to protozoan|
|positive regulation of interleukin-4 production|
|response to protozoan|
|positive T cell selection|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|regulation of interleukin-4 production|
|T-helper cell differentiation|
|alpha-beta T cell activation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|positive regulation of interleukin-2 production|
|T cell differentiation involved in immune response|
|dendritic cell differentiation|
|regulation of T-helper cell differentiation|
|CD4-positive, alpha-beta T cell differentiation|
|positive regulation of interleukin-10 production|
|T cell selection|
|negative regulation of toll-like receptor signaling pathway|
|CD4-positive, alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|histone H3 acetylation|
|alpha-beta T cell differentiation|
|regulation of interleukin-10 production|
|regulation of interleukin-2 production|
|histone H4 acetylation|
|positive regulation of DNA binding|
|regulation of CD4-positive, alpha-beta T cell activation|
|alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|T cell activation involved in immune response|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|positive regulation of cytokine biosynthetic process|
|regulation of toll-like receptor signaling pathway|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|regulation of alpha-beta T cell activation|
|positive regulation of cold-induced thermogenesis|
|regulation of cytokine biosynthetic process|
|lymphocyte activation involved in immune response|
|myeloid leukocyte differentiation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|regulation of DNA binding|
|T cell differentiation|
|regulation of T cell differentiation|
|regulation of cold-induced thermogenesis|
|protein acetylation|
|cellular response to interferon-gamma|
|regulation of lymphocyte differentiation|
|positive regulation of binding|
|response to interferon-gamma|
|protein acylation|
|myeloid cell differentiation|
|T cell activation|
|lymphocyte differentiation|
|cell fate commitment|
|regulation of leukocyte differentiation|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|peptidyl-lysine modification|
|regulation of T cell activation|
|leukocyte differentiation|
|transcription factor binding|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|lymphocyte activation|
|sequence-specific DNA binding|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|hemopoiesis|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|immune system development|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|regulation of cytokine production|
|chromatin organization|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|peptidyl-amino acid modification|
|leukocyte activation|
|defense response to other organism|
|cellular response to cytokine stimulus|
|chromosome organization|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.5|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-2.41|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.36|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.35|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.22|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.22|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.2|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.2|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.19|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.18|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.13|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.02|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.99|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.84|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:csk|CSK]]|0.475|
|[[:human genes:p:pag1|PAG1]]|0.412|
|[[:human genes:p:pten|PTEN]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 37/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|6/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1100
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRF4 Expression in NALM6 Cells: 7.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>