IRF8 [The Human Chemical-Genetic Interaction Map Project]

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======= IRF8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRF8
  * **<color #00a2e8>Official Name</color>**: interferon regulatory factor 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3394|3394]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02556|Q02556]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRF8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRF8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601565|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). {ECO:0000250|UniProtKB:P23611, ECO:0000269|PubMed:25122610}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRF-3|
|IRF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|defense response to protozoan|
|response to protozoan|
|positive regulation of interleukin-12 production|
|regulation of interleukin-12 production|
|positive regulation of interferon-gamma production|
|type I interferon signaling pathway|
|cellular response to type I interferon|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|regulation of interferon-gamma production|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|cellular response to biotic stimulus|
|myeloid cell differentiation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|autophagy|
|process utilizing autophagic mechanism|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|phagocytosis|
|defense response to bacterium|
|positive regulation of cytokine production|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|innate immune response|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|defense response to other organism|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|cellular catabolic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8952
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRF8 Expression in NALM6 Cells: 1.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>