IRG1 [The Human Chemical-Genetic Interaction Map Project]

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======= IRG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACOD1
  * **<color #00a2e8>Official Name</color>**: aconitate decarboxylase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=730249|730249]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NK06|A6NK06]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615275|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MmgE PrpD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aconitate decarboxylase activity|
|2-methylcitrate dehydratase activity|
|propionate metabolic process, methylcitrate cycle|
|tolerance induction to lipopolysaccharide|
|cellular response to progesterone stimulus|
|positive regulation of antimicrobial humoral response|
|propionate metabolic process|
|negative regulation of toll-like receptor 2 signaling pathway|
|regulation of antimicrobial humoral response|
|negative regulation of toll-like receptor 4 signaling pathway|
|regulation of toll-like receptor 2 signaling pathway|
|tolerance induction|
|negative regulation of lipopolysaccharide-mediated signaling pathway|
|positive regulation of humoral immune response|
|short-chain fatty acid metabolic process|
|cellular response to interferon-beta|
|regulation of toll-like receptor 4 signaling pathway|
|regulation of lipopolysaccharide-mediated signaling pathway|
|response to interferon-beta|
|embryo implantation|
|negative regulation of toll-like receptor signaling pathway|
|response to progesterone|
|negative regulation of type I interferon production|
|negative regulation of innate immune response|
|regulation of toll-like receptor signaling pathway|
|negative regulation of NF-kappaB transcription factor activity|
|cellular response to ketone|
|negative regulation of response to biotic stimulus|
|positive regulation of reactive oxygen species metabolic process|
|antibiotic metabolic process|
|regulation of type I interferon production|
|regulation of humoral immune response|
|negative regulation of inflammatory response|
|negative regulation of immune response|
|negative regulation of DNA-binding transcription factor activity|
|cellular response to interferon-gamma|
|cellular response to interleukin-1|
|regulation of reactive oxygen species metabolic process|
|female pregnancy|
|response to interferon-gamma|
|cellular response to lipopolysaccharide|
|cellular response to steroid hormone stimulus|
|cellular response to molecule of bacterial origin|
|response to ketone|
|response to interleukin-1|
|negative regulation of defense response|
|multi-multicellular organism process|
|negative regulation of multi-organism process|
|cellular response to biotic stimulus|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|negative regulation of cytokine production|
|response to lipopolysaccharide|
|fatty acid metabolic process|
|response to molecule of bacterial origin|
|response to steroid hormone|
|regulation of inflammatory response|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|cellular response to drug|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|regulation of innate immune response|
|inflammatory response|
|drug metabolic process|
|positive regulation of multi-organism process|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|monocarboxylic acid metabolic process|
|cellular response to organic cyclic compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|immune system development|
|response to bacterium|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|response to lipid|
|positive regulation of immune response|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|defense response to other organism|
|cellular lipid metabolic process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|response to drug|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|mitochondrion|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|regulation of immune system process|
|small molecule metabolic process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15447
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRG1 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>