ISCA2 [The Human Chemical-Genetic Interaction Map Project]

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======= ISCA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ISCA2
  * **<color #00a2e8>Official Name</color>**: iron-sulfur cluster assembly 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=122961|122961]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86U28|Q86U28]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ISCA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ISCA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615317|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269|PubMed:22323289}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fe-S biosyn|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein maturation by [4Fe-4S] cluster transfer|
|protein maturation by iron-sulfur cluster transfer|
|metallo-sulfur cluster assembly|
|iron-sulfur cluster assembly|
|2 iron, 2 sulfur cluster binding|
|4 iron, 4 sulfur cluster binding|
|iron ion binding|
|structural molecule activity|
|cofactor biosynthetic process|
|protein maturation|
|sulfur compound metabolic process|
|mitochondrial matrix|
|cofactor metabolic process|
|mitochondrion|
|small molecule metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.87|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.74|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.72|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.74|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.76|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.78|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.84|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.1|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.13|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.19|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nfu1|NFU1]]|0.616|
|[[:human genes:g:glrx5|GLRX5]]|0.6|
|[[:human genes:i:iba57|IBA57]]|0.598|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.573|
|[[:human genes:s:slc25a26|SLC25A26]]|0.522|
|[[:human genes:d:dld|DLD]]|0.48|
|[[:human genes:n:ndufb5|NDUFB5]]|0.48|
|[[:human genes:m:mipep|MIPEP]]|0.472|
|[[:human genes:c:c12orf65|C12orf65]]|0.472|
|[[:human genes:m:mrps34|MRPS34]]|0.471|
|[[:human genes:h:hars|HARS]]|0.467|
|[[:human genes:s:sucla2|SUCLA2]]|0.463|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.452|
|[[:human genes:m:mrps5|MRPS5]]|0.449|
|[[:human genes:n:ndufb9|NDUFB9]]|0.446|
|[[:human genes:l:lias|LIAS]]|0.446|
|[[:human genes:i:isca1|ISCA1]]|0.444|
|[[:human genes:n:ndufa1|NDUFA1]]|0.443|
|[[:human genes:n:ndufa3|NDUFA3]]|0.443|
|[[:human genes:s:slc25a19|SLC25A19]]|0.44|
|[[:human genes:f:fdx1|FDX1]]|0.439|
|[[:human genes:n:ndufc2|NDUFC2]]|0.435|
|[[:human genes:e:ecsit|ECSIT]]|0.43|
|[[:human genes:n:ndufb11|NDUFB11]]|0.428|
|[[:human genes:t:tufm|TUFM]]|0.42|
|[[:human genes:s:suclg1|SUCLG1]]|0.418|
|[[:human genes:r:rpusd4|RPUSD4]]|0.417|
|[[:human genes:c:c17orf89|C17orf89]]|0.414|
|[[:human genes:m:mrpl23|MRPL23]]|0.411|
|[[:human genes:c:cox16|COX16]]|0.411|
|[[:human genes:r:rbfa|RBFA]]|0.41|
|[[:human genes:t:tpk1|TPK1]]|0.404|
|[[:human genes:t:timm8b|TIMM8B]]|0.403|
|[[:human genes:m:mrps9|MRPS9]]|0.402|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.401|
|[[:human genes:m:mrpl15|MRPL15]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 149/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|5/28|
|bone|4/26|
|breast|9/33|
|central nervous system|6/56|
|cervix|2/4|
|colorectal|3/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|4/21|
|liver|9/20|
|lung|18/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1587
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ISCA2 Expression in NALM6 Cells: 4.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>