ISG20 [The Human Chemical-Genetic Interaction Map Project]

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======= ISG20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ISG20
  * **<color #00a2e8>Official Name</color>**: interferon stimulated exonuclease gene 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3669|3669]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96AZ6|Q96AZ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ISG20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ISG20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604533|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single- stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. {ECO:0000269|PubMed:11401564, ECO:0000269|PubMed:12594219, ECO:0000269|PubMed:16033969, ECO:0000269|PubMed:21036379}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNase T|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|exoribonuclease II activity|
|DNA catabolic process, exonucleolytic|
|U2 snRNA binding|
|U3 snoRNA binding|
|single-stranded DNA 3-5 exodeoxyribonuclease activity|
|U1 snRNA binding|
|exonuclease activity|
|DNA catabolic process|
|3-5-exoribonuclease activity|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|Cajal body|
|negative regulation of viral genome replication|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|response to type I interferon|
|negative regulation of viral life cycle|
|regulation of viral genome replication|
|negative regulation of viral process|
|PML body|
|regulation of viral life cycle|
|RNA phosphodiester bond hydrolysis|
|defense response to virus|
|regulation of viral process|
|rRNA processing|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|rRNA metabolic process|
|RNA catabolic process|
|response to virus|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|cytokine-mediated signaling pathway|
|DNA metabolic process|
|innate immune response|
|regulation of multi-organism process|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|defense response to other organism|
|cellular response to cytokine stimulus|
|macromolecule catabolic process|
|immune effector process|
|response to cytokine|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10599
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ISG20 Expression in NALM6 Cells: 2.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>