ISY1-RAB43 [The Human Chemical-Genetic Interaction Map Project]

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======= ISY1-RAB43 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/A
  * **<color #00a2e8>Official Name</color>**: N/A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: N/A
  * **<color #00a2e8>UniProt</color>**: N/A
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ISY1-RAB43&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ISY1-RAB43|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in pre-mRNA splicing. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Isy1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.8|
|[[:results:exp539|42°C R08 exp539]]|-1.71|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.71|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.71|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.72|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.74|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.8|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.81|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.83|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.85|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.89|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.89|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.92|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.93|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.01|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.04|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.07|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.1|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.14|
|[[:results:exp331|A-769662 20μM R07 exp331]]|2.16|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.17|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.43|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.52|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|2.76|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1405
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ISY1-RAB43 Expression in NALM6 Cells: 2.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>