ITGA1 [The Human Chemical-Genetic Interaction Map Project]

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======= ITGA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGA1
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3672|3672]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56199|P56199]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192968|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. {ECO:0000269|PubMed:15592458}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FG-GAP|
|VWA|
|Integrin alpha2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alpha1-beta1 complex|
|collagen binding involved in cell-matrix adhesion|
|basal part of cell|
|positive regulation of phosphoprotein phosphatase activity|
|integrin complex|
|vasodilation|
|positive regulation of phosphatase activity|
|cellular extravasation|
|positive regulation of protein dephosphorylation|
|negative regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of ERBB signaling pathway|
|positive regulation of neuron apoptotic process|
|positive regulation of blood vessel diameter|
|positive regulation of dephosphorylation|
|collagen binding|
|neutrophil chemotaxis|
|regulation of epidermal growth factor receptor signaling pathway|
|protein phosphatase binding|
|acrosomal vesicle|
|granulocyte chemotaxis|
|regulation of ERBB signaling pathway|
|neutrophil migration|
|positive regulation of neuron death|
|integrin-mediated signaling pathway|
|granulocyte migration|
|regulation of phosphoprotein phosphatase activity|
|cell-matrix adhesion|
|myeloid leukocyte migration|
|perikaryon|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of protein dephosphorylation|
|regulation of tube size|
|leukocyte chemotaxis|
|activation of MAPK activity|
|vascular process in circulatory system|
|regulation of phosphatase activity|
|cell-substrate adhesion|
|regulation of neuron apoptotic process|
|cell chemotaxis|
|regulation of dephosphorylation|
|membrane raft|
|muscle contraction|
|positive regulation of MAP kinase activity|
|muscle system process|
|regulation of neuron death|
|neuron projection|
|activation of protein kinase activity|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|extracellular matrix organization|
|regulation of MAP kinase activity|
|leukocyte migration|
|extracellular structure organization|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|focal adhesion|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of kinase activity|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|neuron projection development|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|cell morphogenesis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|regulation of kinase activity|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of transferase activity|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7003
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGA1 Expression in NALM6 Cells: 2.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>